Studie van de nucleaire functie van PDZ domein-fosfatidylinositol 4,5-bisfosfaat interacties in cellulaire en ontwikkelingsprogramma's. KU Leuven
PDZ proteins appear crucial in the maintenance of neuronal and epithelial polarity. And until recently, most studies tended to explain this function by an organizational role at the cell cortex, and by the property of PDZ domains to function as protein-interaction modules, recognizing short peptide sequences situated at the C-terminal end of transmembrane receptors. Our recent studies have revealed that PDZ domains can also interact with ...