E-cadherin: From epithelial glue to immunological regulator. Vrije Universiteit Brussel
E-cadherin is best known as a central molecule in adherens junctions, joining adjacent epithelial cells together, thereby safeguarding epithelial barrier function. However, recent findings have uncovered an immunological role for this adhesion molecule, linked to its expression in dendritic cells (DCs) and alternatively activated macrophages and its impact on intracellular signaling pathways. In this respect, E-cadherin has been shown to ...