Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus Universiteit Antwerpen
Both obesity and being underweight have been associated with increased mortality1, 2. Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m2 in adults and ≤ −2 standard deviations from the mean in children, is the main sign of a series of heterogeneous clinical conditions including failure to thrive3, 4, 5, feeding and eating disorder and/or anorexia nervosa6, 7. In contrast to obesity, few genetic variants underlying these clinical ...