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Chromosomal aneuploidy in embryos conceived with unstimulated cycle IVF. Vrije Universiteit Brussel

Willem Verpoest, Bart Fauser, Evangelos Papanikolaou, Catherine Staessen, Lisbet Van Landuyt, Herman Tournaye, Ingeborg Liebaers, Paul Devroey
There is an ever increasing trend in reproductive medicine to reduce the intensity of ovarian stimulation for in vitro fertilization (IVF) and to restrict the number of embryos that are transferred into the uterine cavity. Recent findings suggest that the magnitude of ovarian stimulation affects the proportion of euploid embryos. As a result of the restriction in the number of embryos transferred, it becomes even more important to select the ...

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing Vrije Universiteit Brussel

Rossella Mazzilli, Danilo Cimadomo, Alberto Vaiarelli, Antonio Capalbo, Lisa Dovere, Erminia Alviggi, Ludovica Dusi, Carlo Foresta, Francesco Lombardo, Andrea Lenzi, et al.

OBJECTIVE: To evaluate the impact of the male factor on the outcomes of intracytoplasmic sperm injection (ICSI) cycles combined with preimplantation genetic testing for aneuploidies (PGT-A).

DESIGN: Observational longitudinal cohort study.

SETTING: Private in vitro fertilization (IVF) center.

PATIENT(S): A total of 1,219 oocyte retrievals divided into five study groups according to sperm parameters: normozoospermia ...

Aneuploidy in oocytes from women of advanced maternal age Vrije Universiteit Brussel

Pieter Verdyck, Gheona Altarescu, S. Santos-Ribeiro, C Vrettou, Ulrich Koehler, G. Griesinger, Veerle Goossens, Cristini Magli, C ALBANESE, Monica Parriego, et al.

STUDY QUESTION: In oocytes of advanced maternal age (AMA) women, what are the mechanisms leading to aneuploidy and what is the association of aneuploidy with embryo development?

SUMMARY ANSWER: Known chromosome segregation errors such as precocious separation of sister chromatids explained 90.4% of abnormal chromosome copy numbers in polar bodies (PBs), underlying impaired embryo development.

WHAT IS KNOWN ALREADY: Meiotic ...

Chemically induced aneuploidy in germ cells. Part II of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases Vrije Universiteit Brussel

Francesca Pacchierotti, Kenichi Masumura, David A Eastmond, Azeddine Elhajouji, Roland Froetschl, Micheline Volders, Anthony Lynch, Maik Schuler, David Tweats, Francesco Marchetti, et al.

As part of the 7th International Workshops on Genotoxicity Testing held in Tokyo, Japan in November 2017, a workgroup of experts reviewed and assessed the risk of aneugens for human health. The present manuscript is one of three manuscripts from the workgroup and reports on the unanimous consensus reached on the evidence for aneugens affecting germ cells, their mechanisms of action and role in hereditary diseases. There are 24 chemicals with ...

Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania Universiteit Antwerpen Instituut voor Tropische Geneeskunde Universiteit Hasselt

Bart Cuypers, Pieter Meysman, Ionas Erb, Wout Bittremieux, Dirk Valkenborg, Geert Baggerman, Inge Mertens, Shyam Sundar, Basudha Khanal, Cedric Notredame, et al.
Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequences for the pathogen remain poorly understood. Here, we addressed this question in vitro and present the first integrated analysis of the genome, ...

Higher limb asymmetry in deceased human fetuses and infants with aneuploidy Universiteit Antwerpen

Jessica Bots, Claartje ten Broek, Jeroen A.M. Belien, Marianna Bugiani, Frietson Galis, Stefan Van Dongen
Aneuploidies cause gene-dosage imbalances that presumably result in a generalized decreased developmental homeostasis, which is expected to be detectable through an increase in fluctuating asymmetry (FA) of bilateral symmetric traits. However, support for the link between aneuploidy and FA is currently limited and no comparisons among different aneuploidies have been made. Here, we study FA in deceased human fetuses and infants from a 20-year ...

Investigating aneuploidy and mosaicism as a mechanism for survival and adaptation of Leishmania Universiteit Antwerpen

Gabriel Heringer Negreira
Leishmania is a protozoan parasite causing a neglected tropical disease known as leishmaniasis, which is fatal in visceral infections if untreated. Few drugs are available for treatment and the emergence of drug resistance poses a threat to current elimination efforts. Leishmania has a plastic genome characterized by dynamic modulation of chromosomes copy number (aneuploidy), which leads to different karyotypes co-existing in clonal populations ...

Marginal differences in preimplantation morphokinetics between conventional IVF and ICSI in patients with preimplantation genetic testing for aneuploidy (PGT-A) Vrije Universiteit Brussel

Neelke De Munck, Aşina Bayram, Ibrahim ElKhatib, Andrea Abdala, Ana Arnanz, Laura Melado, Barbara Lawrenz, Human Mousavi Fatemi

OBJECTIVE: This study aimed to analyze the morphokinetic behaviour between conventional IVF and ICSI, in cycles with preimplantation genetic testing for aneuploidies (PGT-A).

MATERIALS: A randomized controlled trial (NCT03708991) was conducted in a private fertility center. Thirty couples with non-male factor infertility were recruited between November 2018 and April 2019. A total of 568 sibling cumulus oocyte complexes were randomly ...

Role of aneuploidy in the carcinogenic process Vrije Universiteit Brussel

David Tweats, David A Eastmond, Anthony M. Lynch, Azeddine Elhajouji, Roland Froetschl, Micheline Volders, Francesco Marchetti, Kenichi Masumura, Francesca Pacchierotti, Maik Schuler, et al.

Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between ...

Risks of aneuploidy induction from chemical exposure Vrije Universiteit Brussel

Micheline Volders, Francesca Pacchierotti, Elizabeth M Parry, Antonella Russo, Ursula Eichenlaub-Ritter, Ilse-Dore Adler

Although Theodor Boveri linked abnormal chromosome numbers and disease more than a century ago, an in-depth understanding of the impact of mitotic and meiotic chromosome segregation errors on cell proliferation and diseases is still lacking. This review reflects on the efforts and results of a large European research network that, from the 1980's until 2004, focused on protection against aneuploidy-inducing factors and tackled the following ...