Pharmacological targeting of de novo serine/glycine synthesis KU Leuven
The invention relates to sertraline for use in the treatment of a cancer with increased serine/glycine synthesis, such as certain types of breast cancer or T-cell acute lymphoblastic leukaemia. Increased serine/glycine synthesis is for example obtained via increased expression of PSPH, PHGDH, PSAT1, SHMT1 or SHMT2.