Publicaties
Long-term impact of zinc supplementation in sows: Impact on zinc status biomarkers and performance Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Zinc (Zn) metabolism changes throughout the reproductive cycle of sows to support fetal growth and development and milk production, as found in women.1-3 The underlying physiological processes seem to regulate these adaptations, but other factors, such as dietary Zn concentration, may affect the capacity to adapt. Across species, insufficient dietary Zn intake during gestation and lactation may result in reproductive failure.4-6 In sows, dietary ...
Effects of separate delivery of zinc or zinc and vitamin A on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anaemia Instituut voor Tropische Geneeskunde
Zinc status assessment and the impact of dietary zinc on claw quality in pigs Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Klauwproblemen en kreupelheid bij varkens zijn multifactoriële aandoeningen en zijn een belangrijk aandachtspunt voor het dierenwelzijn en de rentabiliteit van het bedrijf. Bijna alle zeugen hebben één of meer klauwproblemen, variërend in type en ernst. Om klauwproblemen bij varkens te voorkomen, moet de kwaliteit van de klauw gehandhaafd blijven zodat de hoornproductie optimaal blijft. Zink, als essentieël micromineraal, is belangrijk voor veel ...
High Temperature-Induced Oxidative Stress Affects Systemic Zinc Homeostasis in Broilers by Regulating Zinc Transporters and Metallothionein in the Liver and Jejunum KU Leuven
To investigate the change in zinc homeostasis of broilers under heat stress, 512 broiler chickens were raised to the age of 28 days. The broilers were then assigned to heat stress and normal temperature (36.0°C vs. 26.0°C) groups for 7 days. The results showed that oxidative stress induced by high temperature had a negative effect on the growth performance of broilers. Heat stress altered zinc homeostasis and led to a redistribution of zinc in ...
Selective recovery of zinc from goethite residue in the zinc industry using deep-eutectic solvents KU Leuven
Several deep-eutectic solvents (DESs) were tested for the valorisation of goethite residue produced by the zinc industry. The objective of the work was to selectively recover zinc from the iron-rich matrix using deep-eutectic solvents as lixiviants. The effect of the type of hydrogen bond donor and hydrogen bond acceptor of the deep-eutectic solvent on the leaching efficiency was studied. Levulinic acid-choline chloride (x ChCl = 0.33) ...
A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions KU Leuven
BACKGROUND: Sexual acquisition of the human immunodeficiency virus (HIV) through mucosal transmission may be prevented by using topically applied agents that block HIV transmission from one individual to another. Therefore, virucidal agents that inactivate HIV virions may be used as a component in topical microbicides. RESULTS: Here, we have identified 2-methyl-3-phenyl-2H-[1,2,4]thiadiazol-5-ylideneamine (WDO-217) as a low-molecular-weight ...
Inhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingers KU Leuven
The human immunodeficiency virus type 1 (HIV-1) nucleocapsid p7 (NCp7) protein holds two highly conserved "CCHC" zinc finger domains that are required for several phases of viral replication. Basic residues flank the zinc fingers, and both determinants are required for high-affinity binding to RNA. Several compounds were previously found to target NCp7 by reacting with the sulfhydryl group of cysteine residues from the zinc fingers. Here, we ...