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Maternal anaemia and duration of zidovudine in antiretroviral regimens for preventing mother-to-child transmission : a randomized trial in three African countries Universiteit Gent

Benn KD Sartorius, Matthew Chersich, Mary Mwaura, Nicolas Meda, Marleen Temmerman, Marie Louise Newell, Timothy Farley, Stanley Lüchters

Background: Although substantiated by little evidence, concerns about zidovudine-related anaemia in pregnancy have influenced antiretroviral (ARV) regimen choice for preventing mother-to-child transmission of HIV-1, especially in settings where anaemia is common. Methods: Eligible HIV-infected pregnant women in Burkina Faso, Kenya and South Africa were followed from 28 weeks of pregnancy until 12-24 months after delivery (n = 1070). Women with a ...

Risk factors of treatment-limiting anemia after substitution of zidovudine for stavudine in HIV-infected adult patients on antiretroviral treatment Instituut voor Tropische Geneeskunde

T Phe, S. Thai, C. Veng, S. Sok, Lut Lynen, Johan van Griensven

BACKGROUND: Anemia is the main concern among patients using a zidovudine (AZT)-based antiretroviral treatment (ART). Some studies suggested weight-adjusted AZT dosing as a way to reduce toxicity. We analyzed the risk factors associated with AZT-induced anemia in a cohort using AZT as substitution for stavudine (D4T). METHODS: We retrospectively studied HIV-infected patients in a referral hospital in Phnom Penh, Cambodia between 2003 and 2011. ...

Zidovudine to prevent mother to infant transmission in developing countries: many questions! [letter] Instituut voor Tropische Geneeskunde

Patrick Van der Stuyft, Marleen Boelaert, M Temmerman

Zidovudine against mother-to-child HIV transmission [letter] Instituut voor Tropische Geneeskunde

Robert Colebunders, Y Coppieters

Zidovudine to prevent mother-to-infant HIV transmission in developing countries: any questions? [editorial] Instituut voor Tropische Geneeskunde

Patrick Van der Stuyft, Marleen Boelaert, M Temmerman

Ethical issues in the use of zidovudine to reduce vertical transmission of HIV [letter] Instituut voor Tropische Geneeskunde

Ann De Roo, Robert Colebunders

Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter Instituut voor Tropische Geneeskunde

DA Cooper, JM Gatell, S Kroon, N Clumeck, J Millard, FD Goebel, JN Bruun, G Stingi, RL Melville, J González-Lahoz, et al.

The efficacy and safety of zidovudine alone or as cotherapy with acyclovir for the treatment of patients with AIDS and AIDS-related complex; a double-blind, randomized trial Instituut voor Tropische Geneeskunde

DA Cooper, PO Pehrson, C Pedersen, M Moroni, E Oksenhendler, W Rozenbaum, N Clumeck, V Faber, W Stille, B Hirschel, et al.

The efficacy and safety of zidovudine with or without acyclovir in the treatment of patients with AIDS-related complex Instituut voor Tropische Geneeskunde

DA Cooper, C Pedersen, F Aiuti, JL Vilde, M Ruhnke, O Pehrson, N Clumeck, C Farthing, L Rüedi, RR Doherty, et al.

Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates KU Leuven

Christophe Pannecouque, Erik De Clercq

A series of methoxy poly(ethylene glycol)-succinyl-5'-O-zidovudine conjugates (mPEG-succinyl-AZT) with different molecular weight (M(w): 750Da, 2, 5 or 10kDa) of mPEG were synthesized and characterized by Fourier transform infrared (FTIR) spectroscopy, (1)H nuclear magnetic resonance ((1)H NMR) spectroscopy, and matrix-assisted laser desorption/ionization time of flight mass (MALDI TOF MS) spectrometry analysis. All conjugates showed good ...

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