Novel Research Horizons for Presenilins and gamma-Secretases in Cell Biology and Disease KU Leuven
Presenilins are the catalytic subunits of larger tetrameric gamma-secretase complexes. The degradome of these aspartyl proteases consists of at least 60 different substrates. gamma-Secretase is key to regulated intramembrane proteolysis, releasing protein fragments that potentially transduce signals at both sides of the cell membrane. Characteristic for this novel form of cellular signaling is its irreversible nature, providing direction to ...