Vitamin D analog TX 527 down-regulates the NFκB pathway and controls the proliferation of endothelial cells transformed by Kaposi sarcoma herpesvirus KU Leuven
BACKGROUND AND PURPOSE: The Kaposi Sarcoma-associated herpesvirus G protein-coupled receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi Sarcoma, where it increases Nuclear Factor kappa B (NFκB) gene expression and activates the NFκB pathway. We investigated whether the less calcemic vitamin D analog TX 527 inhibited the proliferation of endothelial cells transformed by vGPCR by modulation of the NFκB pathway. EXPERIMENTAL APPROACH: ...