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Orthopox viral diseases Instituut voor Tropische Geneeskunde
Orthopox viral diseases Instituut voor Tropische Geneeskunde
Drug design strategies against newly emerging viral diseases KU Leuven
The proposed project aims at the structure-based design of novel selective inhibitors for the treatment of specific vector-borne diseases mainly parasitic (schistosomiasis, human African trypanosomiasis, leishmaniasis, Chagas disease) and viral hemorrhagic fevers. It will be a challenging task to find those compounds that have maximal efficacy against the intruder, but minimal toxicity for the host as the differences between few parasitic target ...
A scoping review of viral diseases in African ungulates Instituut voor Tropische Geneeskunde
(1) Background: Viral diseases are important as they can cause significant clinical disease in both wild and domestic animals, as well as in humans. They also make up a large proportion of emerging infectious diseases. (2) Methods: A scoping review of peer-reviewed publications was performed and based on the guidelines set out in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. (3) ...
Human inherited complete STAT2 deficiency underlies inflammatory viral diseases KU Leuven
STAT2 is a transcription factor activated by type I and III IFNs. We report 23 patients with loss-of-function variants causing autosomal recessive (AR) complete STAT2 deficiency. Both cells transfected with mutant STAT2 alleles and the patients' cells displayed impaired expression of IFN-stimulated genes and impaired control of in vitro viral infections. Clinical manifestations from early childhood onward included severe adverse reaction to live ...
Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases Vrije Universiteit Brussel
Herpesviruses are ubiquitous pathogens that establish lifelong, latent infections in their host. Spontaneous reactivation of herpesviruses is often asymptomatic or clinically manageable in healthy individuals, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with multiple proliferative cardiovascular and post-transplant ...
Current Status and Prospects of Viral Vector-Based Gene Therapy to Treat Kidney Diseases. KU Leuven
Inherited kidney diseases are among the leading causes of chronic kidney disease, reducing the quality of life and resulting in substantial socioeconomic impact. The advent of early genetic testing and the growing understanding of the molecular basis and pathophysiology of these disorders have opened avenues for novel treatment strategies. Viral vector-based gene therapies have evolved from experimental treatments for rare diseases to potent ...
Advances in Visualization Tools for Phylogenomic and Phylodynamic Studies of Viral Diseases KU Leuven
Genomic and epidemiological monitoring have become an integral part of our response to emerging and ongoing epidemics of viral infectious diseases. Advances in high-throughput sequencing, including portable genomic sequencing at reduced costs and turnaround time, are paralleled by continuing developments in methodology to infer evolutionary histories (dynamics/patterns) and to identify factors driving viral spread in space and time. The ...