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A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve: pilot trial at Ghent University Hospital Universiteit Antwerpen

Riëm el Tahry, Robrecht Raedt, Lies Mollet, Veerle de Herdt, Tine Wyckhuys, Annelies van Dycke, Alfred Meurs, Frank Dewaele, Dirk van Roost, Pascal Doguet, et al.
Purpose Vagus nerve stimulation (VNS) is an established treatment for refractory epilepsy. The ADNS-300 is a new system for VNS that includes a rechargeable stimulus generator and an electrode for combined stimulation and recording. In this feasibility study, three patients were implanted with ADNS-300 for therapeutic VNS. In addition, compound action potentials (CAPs) were recorded to evaluate activation of the vagus nerve in response to VNS. ...

Stimulation pattern efficiency in percutaneous auricular vagus nerve stimulation : experimental versus numerical data Universiteit Gent

Eugenijus Kaniusas, Mohammed Samoudi, Stefan Kampusch, Katarzyna Bald, Emmeric Tanghe, Luc Martens, Wout Joseph, Jozsef Constantin Széles
Objective: Percutaneous electrical stimulation of the auricular vagus nerve (pVNS) is an electroceutical technology. The selection of stimulation patterns is empirical, which may lead to under-stimulation or over-stimulation. The objective is to assess the efficiency of different stimulation patterns with respect to individual perception and to compare it with numerical data based on in-silico ear models. Methods: Monophasic (MS), biphasic (BS) ...

Assessment of nerve cathodal block for the percutaneous auricular vagus nerve stimulation Universiteit Gent

Mohammed Samoudi, Tom Van de Steene, Emmeric Tanghe, Luc Martens, Wout Joseph
Nerve cathodal block mechanism for the percutaneous auricular vagus nerve stimulation is investigated. The response of individual axons to stimulation will be assessed in terms of excitation, blocking and propagation of action potentials in order to optimize stimulation patterns. It was seen that the response obeyed the activating function remarkably well. The found sensitivity indices of the blocking threshold for variations in diameter and ...

Effects of short and prolonged transcutaneous vagus nerve stimulation on heart rate variability in healthy subjects Vrije Universiteit Brussel KU Leuven

Marijke De Couck, Renata Cserjesi, Ralf Caers, W P Zijlstra, D Widjaja, Nicole I Wolf, O. Luminet, J Ellrich, Yori Gidron

The vagus nerve is strategically located in the body, and has multiple homeostatic and health-promoting effects. Low vagal activity predicts onset and progression of diseases. These are the reasons to activate this nerve. This study examined the effects of transcutaneous vagus nerve stimulation (t-VNS) on a main index of vagal activity, namely heart rate variability (HRV). In Study 1, we compared short (10min) left versus right ear t-VNS ...

Numerical modeling of percutaneous auricular vagus nerve stimulation : a realistic 3D model to evaluate sensitivity of neural activation to electrode position Universiteit Gent

Mohammed Samoudi, Stefan Kampusch, Emmeric Tanghe, Jozsef C. Szeles, Luc Martens, Eugenijus Kaniusas, Wout Joseph
Percutaneous stimulation of the auricular branch of the vagus nerve (pVNS) by miniaturized needle electrodes in the auricle gained importance as a treatment for acute and chronic pain. The objective is to establish a realistic numerical model of pVNS and investigate the effects of stimulation waveform, electrodes' depth, and electrodes' position on nerve excitation threshold and the percentage of stimulated nerves. Simulations were performed ...