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The partnership for influenza vaccine introduction (PIVI): supporting influenza vaccine program development in low and middle-income countries through public-private partnerships Instituut voor Tropische Geneeskunde
Influenza vaccination remains the most effective tool for reducing seasonal influenza disease burden. Few Low and Middle-Income Countries (LMICs) have robust, sustainable annual influenza national vaccination programs. The Partnership for Influenza Vaccine Introduction (PIVI) was developed as a public-private partnership to support LMICs to develop and sustain national vaccination programs through time-limited vaccine donations and technical ...
TSOL18 vaccine of Taenia solium: development of monoclonal antibodies and field testing of the vaccine in Cameroon Universiteit Gent
Chapter 1 reviews the literature about the immunological aspects of taeniid cestode infections and the existing vaccines against Taenia solium cysticercosis in pigs. One of the most promising vaccines is TSOL18, a protein that has been identified in the oncosphere of Taenia solium and expressed as a recombinant molecule in E. coli. Repeated experimental trials have shown that this vaccine is able to protect up to 100 % of the immunised pigs ...
TSOL18 vaccine antigen of Taenia solium: development of monoclonal antibodies and field testing of the vaccine in Cameroon Instituut voor Tropische Geneeskunde
Causal inference concepts applied to three observational studies in the context of vaccine development : from theory to practice Universiteit Gent
Background Randomized controlled trials are considered the gold standard to evaluate causal associations, whereas assessing causality in observational studies is challenging. Methods We applied Hill's Criteria, counterfactual reasoning, and causal diagrams to evaluate a potentially causal relationship between an exposure and outcome in three published observational studies: a) one burden of disease cohort study to determine the association ...
Dendritic cells loaded with gag mRNA from HIV quasispecies for the development of a cellular therapeutic vaccine Instituut voor Tropische Geneeskunde
Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development Universiteit Gent
The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector ...
Current status and progress of prepandemic and pandemic influenza vaccine development Universiteit Gent
H5N1 viruses are widely considered to be a probable cause of the next influenza pandemic Influenza vaccines are considered to form the main prophylactic measure against pandemic influenza. The world's population is expected to have no pre-existing immunity against the pandemic virus strain and will need two vaccine doses to acquire protective immunity. A pandemic outbreak will spread much faster than it will take for pandemic vaccines to be ...
Current status of COVID-19 (pre)clinical vaccine development Universiteit Gent
The current COVID-19 pandemic has a tremendous impact on daily life world-wide. Despite the ability to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive interventions, it is believed that only effective vaccines will provide sufficient control over the disease and revert societal live back to normal. At present, a double-digit number of efforts are devoted to the development of a vaccine against COVID-19. ...