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Impact of HIV-1 infection on the humoral immune response to yellow fever vaccination: contribution to the development of a yellow fever vaccination schedule for patients living with HIV Instituut voor Tropische Geneeskunde

Charlotte Martin
Since the advent of modern and universal ART in our countries, PLWH have a life expectancy and lifestyle comparable to the general population. Many of them are travelling, either for tourism or to visit friends and relatives (VFR), including to yellow fever (YF) endemic destinations. They are therefore likely to be vaccinated against yellow fever. Since 2016, WHO guarantees administrative validity for life after YF vaccination, except for PLWH ...

Pre-exposure intradermal rabies vaccination: a non-inferiority trial in healthy adults on shortening the vaccination schedule from 28 to 7 days Instituut voor Tropische Geneeskunde Universiteit Antwerpen

Patrick Soentjens, P Andries, A Aerssens, Achilleas Tsoumanis, Raffaella Ravinetto, W Heuninckx, Harry van Loen, B Brochier, S. Van Gucht, P Van Damme, et al.

Background: The existing 4-week preexposure rabies vaccination schedule is costly and often not practicable. Shorter effective schedules would result in wider acceptance.

Methods: We conducted a noninferiority trial in 500 healthy adults comparing the safety and immunogenicity of a 2-visit (days 0 and 7) intradermal (ID) primary vaccination (2 doses of 0.1 mL ID of the human diploid cell culture rabies vaccine [HDCV] at days 0 and 7) ...

Vaccinations in patients receiving systemic drugs for skin disorders : what can we learn for SARS-Cov-2 vaccination strategies? Universiteit Gent

Reinhart Speeckaert, Jo Lambert, Luis Puig, Marijn Speeckaert, Hilde Lapeere, Sofie De Schepper, Nanja van Geel
Large-scale vaccination strategies are currently being deployed against severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2). Whether systemic medication for skin diseases affects the efficacy of vaccination and whether temporary interruption or extension of the dosing interval is necessary is under debate. Most immunomodulating/immunosuppressive drugs only affect vaccine-induced immune responses to a limited or moderate extent, ...

The life-course approach to vaccination: Harnessing the benefits of vaccination throughout life Universiteit Antwerpen

Jody Tate, Teresa Aguado, Jan De Belie, Daphne Holt, Emilie Karafillakis, Sam Nye, David Salisbury, Mariano Votta, Suzanne Wait
Vaccination beyond childhood brings significant benefits at the individual, community and socio-economic levels. Despite this, immunisation programmes often fail to deliver the vaccines which could protect those at risk of vaccine-preventable diseases. In this commentary, we argue that the benefits of vaccination beyond childhood must be more widely understood and furthermore, that action must be taken by policymakers, healthcare professionals ...

Hepatitis B virus vaccination and revaccination response in children diagnosed with coeliac disease : a multicentre prospective study Universiteit Gent

THAIS ROUSSEFF, TANIA CLAEYS, Els Van de Vijver, N Moes, Saskia Vande Velde, Petra Schelstraete, Ruth De Bruyne, Myriam Van Winckel, Stephanie Van Biervliet
Aim : This study evaluates hepatitis B virus (HBV) vaccination response in children with celiac disease (CD). Response in initial non-responders after a single booster vaccination as well as factors influencing HBV vaccination response were evaluated. Methodology : Anti-hepatitis B surface antibodies (a-HBsAB) were checked in all children with CD and a documented complete HBV vaccination. An a-HBsAB <10 U/L was considered as non-response. A ...

Protecting the vaccinating population in the face of a measles epidemic: assessing the impact of adjusted vaccination schedules Instituut voor Tropische Geneeskunde

S van den Hof, Jacco Wallinga, M A E Conyn-van Spaendonck

We investigated which vaccination schedule gives best protection to the vaccinating population, in case there is a measles epidemic in an area with low vaccine coverage. We considered combinations of an early measles vaccination (none, at 6 months or at 9 months), a measles-mumps-rubella (MMR) vaccination around the first birthday (at either 11 or 14 months), and MMR vaccination at an older age (at either 4 or 9 years). The different ...

Identifying and addressing barriers and opportunities for bovine respiratory disease complex vaccination : a consensus paper on practical recommendations for best practise vaccination Universiteit Gent

Matt Yarnall, Federica Amovilli, Sébastien Assié, Jade Bokma, Matt Pugh, Dirk Werling
Many questions are raised, and challenges faced in the new era of (intranasal) bovine respiratory disease complex vaccination. An increase in vaccination rate is expected, due to its positive impact on cattle health, reduction of antimicrobial use and economic factors. However, engagement of farmers and veterinarians with regard to vaccination is often affected by limitations, resulting in the development of barriers to vaccination, but also ...

Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy Universiteit Hasselt Universiteit Antwerpen

Ha Thi Thu Hoang, Elke Leuridan, Kirsten Maertens, Trung Dac Nguyen, Niel HENS, Ngoc Ha Vu, Raissa Nadege Cabore, Hong Thi Duong, Kris Huygen, Pierre Van Damme, et al.
A pertussis vaccination during pregnancy has recently been adopted in several countries to indirectly protect young infants. This study assessed the effect of adding a pertussis component to the tetanus vaccination, in the pregnancy immunization program in Vietnam. A randomized controlled trial was performed. Pregnant women received either a Tdap (tetanus, diphtheria acellular pertussis) vaccine or a tetanus only vaccine between 19 and 35 weeks' ...

Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age Universiteit Hasselt Universiteit Antwerpen

Kirsten Maertens, Raissa Nadege Cabore, Kris Huygen, Sandra Vermeiren, Niel HENS, Pierre Van Damme, Elke Leuridan
Vaccination of pregnant women with a pertussis containing vaccine is a recommended strategy in some industrialized countries, to protect young infants from severe disease. One of the effects of the presence of high titers of passively acquired maternal antibodies in young infants is blunting of immune responses to infant vaccination. We present infant immune responses to a fourth pertussis containing vaccine dose at 15 months of age, as a ...