The role of sclerostin in vascular calcification and the calcification paradox Universiteit Antwerpen
Ectopic vascular calcification involves the deposition of calcium-phosphate crystals in the medial layer of the arterial wall. Although vascular calcification is part of the normal aging process, it is accelerated in patients with chronic kidney disease (CKD), diabetes and other metabolic disorders. In these patient populations, vascular calcification importantly contributes to increased morbidity and mortality. An imbalance in osteochondrogenic ...