Publicaties
Gekozen filters:
Gekozen filters:
Retrospective evaluation of therapeutic drug monitoring of clozapine and norclozapine in Belgium using a multidrug UHPLC-MS/MS method Vrije Universiteit Brussel Universiteit Antwerpen
OBJECTIVE: Clozapine is an atypical antipsychotic with a narrow therapeutic range and serious toxic side effects. According to AGNP-TDM consensus guidelines, therapeutic drug monitoring (TDM) of clozapine and its metabolite norclozapine is strongly recommended. 330 serum samples, sent to the toxicological laboratory of Ziekenhuis Netwerk Antwerpen for monitoring of clozapine, were tested with a new ultra-high performance liquid ...
Development and validation of a quantitative UHPLC-MS/MS method for selected brominated flame retardants in food KU Leuven Universiteit Antwerpen
An ultra-high performance liquid chromatography - tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated (in-house) for the quantification of selected brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), hexabromocyclododecanes (HBCDs), tetrabromobisphenol S (TBBPS) and bromophenols (BPs), in various food matrices. The sample preparation consisted of extraction of TBBPS with acidified acetonitrile ...
A validated UHPLC-MS/MS method to quantify low levels of anabolic-androgenic steroids naturally present in urine of untreated horses Universiteit Gent
Optimization of a sample preparation workflow based on UHPLC-MS/MS method for multi-allergen detection in chocolate: An outcome of the ThRAll project Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Developing reliable methodologies for detecting and quantifying allergens in processed food commodities is crucial to support food business operators in allergen risk assessment and properly implementing precautionary allergen labels whenever required to safeguard the health of allergic consumers. Multiple Mass Spectrometry (MS) methods have been developed so far and applied for single and multi-allergen detection in foods, generating a ...
Development and validation of a reliable UHPLC-MS/MS method for simultaneous quantification of Macrocyclic lactones in bovine plasma Universiteit Gent
Multi-Class UHPLC-MS/MS Method for Plant Toxins and Cyanotoxins in Food Supplements and Application for Belgian Market Samples (#) Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
The presence of plant toxins and/or cyanotoxins in food supplements implies consumer health risks. Therefore, a targeted ultra-high performance liquid chromatographic-tandem mass spectrometric method to detect/quantify 25 toxins simultaneously in food supplement formulations was developed and validated. Full validation for tablets/powders and secondary validation for a liquid and soft gel capsule indicated that most compounds were efficiently ...
Development of a sensitive and quantitative UHPLC-MS/MS method to study the whole-body uptake of pharmaceuticals in zebrafish KU Leuven
An analytical procedure to measure the whole-body uptake of pharmaceuticals in zebrafish has been developed using state-of-the-art methodologies. A sample preparation procedure for 9 pharmaceuticals displaying a variety in physicochemical properties was developed using 10-day old zebrafish (TG898). For an efficient homogenization of the samples and subsequent recovery of the compounds of interest, different amounts of organic solvents in ...
Miniaturized UHPLC-MS/MS for the in vivo quantification of neuropeptides in microdialysis samples - Strategies to increase method sensitivity. Vrije Universiteit Brussel
To better understand the physiological and pathophysiological conditions underlying health and disease, an increasing amount of research has been performed to monitor endogenous molecules, such as peptides, present in the body. One organ receiving a lot of interest in particularly is the central nervous system (CNS). Hand in hand with the increasing life expectancy, expanding population and better diagnostics, neuroscience is a continuously ...