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Does pre-emptive transplantation versus post start of dialysis transplantation with a kidney from a living donor improve outcomes after transplantation? A systematic literature review and position statement by the Descartes Working Group and ERBP Universiteit Antwerpen Universiteit Gent

Daniel Abramowicz, Marc Hazzan, Umberto Maggiore, Licia Peruzzi, Pierre Cochat, Rainer Oberbauer, Maria C. Haller, Wim Van Biesen
This position statement brings up guidance on pre-emptive kidney transplantation from living donors. The provided guid- ance is based on a systematic review of the literature.

Reduced-intensity conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation : a study by the European Group for Blood and Marrow Transplantation Chronic Malignancies Working Party KU Leuven

HW Auner, R Szydlo, A van Biezen, S Iacobelli, G Gahrton, N Milpled, L Volin, J Janssen, S Nguyen Quoc, M Michallet, et al.
Outcomes and prognostic factors of reduced intensity-conditioned allo-SCT (RIC allo-SCT) for multiple myeloma (MM) relapsing or progressing after prior autologous (auto)-SCT are not well defined. We performed an analysis of 413 MM patients who received a related or unrelated RIC allo-SCT for the treatment of relapse/progression after prior auto-SCT. Median age at RIC allo-SCT was 54.1 years, and 44.6% of patients had undergone two or more prior ...

Ongoing graft-versus-host disease is s risk for azoospermia after allogeneic hematopoietic stem cell transplantation :a survey of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation Universiteit Antwerpen

Alicia Rovó, Mahmoud Aljurf, Sandra Chiodi, Wilfried Schroyens, et al.
The aim of this study was to assess the degree of spermatogenesis defects in sperm analysis in long-term male survivors after allogeneic hematopoietic stem cell transplantation in order to identify the risk factors related to potential infertility after hematopoietic stem cell transplantation and to provide data on longitudinal sperm recovery after hematopoietic stem cell transplantation. Here, the Late Effects Working Party of the European ...

T-Cell-Depleted Haploidentical Stem Cell Transplantation Results Improve With Time in Adults With Acute Leukemia: A Study From the Acute Leukemia Working Party of the European Society of Blood and Marrow Transplantation (EBMT) KU Leuven

Simona Sestili, Myriam Labopin, Annalisa Ruggeri, Andrea Velardi, Fabio Ciceri, Johan Maertens, Lothar Kanz, Franco Aversa, Philippe Lewalle, Donald Bunjes, et al.
BACKGROUND: T-cell-depleted, haploidentical transplantations (haplos) are commonly offered to patients who have high-risk, acute leukemia in the absence of a human leukocyte antigen (HLA) full-matched donor. METHODS: To determine the effect of transplantation period, the authors divided 308 adults with de novo, acute leukemia who underwent T-cell-depleted haplo from 2005 to 2015 into 2 groups, according the year in which they underwent ...

Living related liver transplantation in an adult patient with hepatocellular adenoma and carcinoma 13 years after bone marrow transplantation for Fanconi anemia: a case report Universiteit Gent KU Leuven

Isabelle Colle, Genevieve Laureys, Sarah Raevens, Louis Libbrecht, KOEN REYNTJENS, Anja Geerts, Xavier Rogiers, Roberto Troisi, Holger Hoehn, Detlev Schindler, et al.
Fanconi anemia (FA) is an inherited bone marrow failure syndrome due to defective DNA inter-strand cross-link repair. Hematopoietic stem cell transplantation (HSCT) is curative for pancytopenia, but may not prevent the development of non-hematological malignancies. We describe a 26-year-old male patient with FA and Marfan syndrome who in 1994 underwent successful HSCT with bone marrow stem cells from his human leukocyte antigen (HLA)-identical ...

A consensus document for the selection of lung transplant candidates: 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation KU Leuven

David Weill, Christian Benden, Paul A Corris, John H Dark, R Duane Davis, Shaf Keshavjee, David J Lederer, Michael J Mulligan, G Alexander Patterson, Lianne G Singer, et al.
The appropriate selection of lung transplant recipients is an important determinant of outcomes. This consensus document is an update of the recipient selection guidelines published in 2006. The Pulmonary Council of the International Society for Heart and Lung Transplantation (ISHLT) organized a Writing Committee of international experts to provide consensus opinion regarding the appropriate timing of referral and listing of candidates for lung ...

Rituximab purging and/or maintenance in patients undergoing autologous transplantation for relapsed follicular lymphoma: a prospective randomized trial from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation Vrije Universiteit Brussel

Purpose
The objective of this randomized trial was to assess the efficacy and safety of rituximab as in vivo
purging before transplantation and as maintenance treatment immediately after high-dose
chemotherapy and autologous stem-cell transplantation (HDC-ASCT) in patients with relapsed
follicular lymphoma (FL).
Patients and Methods
Patients with relapsed FL who achieved either complete or very good partial ...

MAPC Transplantation Confers a More Durable Benefit Than AC133(+) Cell Transplantation in Severe Hind Limb Ischemia KU Leuven

Xabier Lopez Aranguren, Beatriz Pelacho, Ivan Penuelas, Gloria Abizanda, Maialen Uriz, Margarita Ecay, Maria Collantaes, Miriam Arana, Manu Beerens, Giulia Coppiello, et al.
There is a need for comparative studies to determine which cell types are better candidates to remedy ischemia. Here, we compared human AC133(+) cells and multipotent adult progenitor cells (hMAPC) in a mouse model reminiscent of critical limb ischemia. hMAPC or hAC133(+) cell transplantation induced a significant improvement in tissue perfusion (measured by microPET) 15 days posttransplantation compared to controls. This improvement persisted ...

High-dose therapy and autologous stem cell transplantation in first relapse for diffuse large B cell lymphoma in the rituximab era: an analysis based on data from the European Blood and Marrow Transplantation Registry KU Leuven

Nicolas Mounier, Carmen Canals, Christian Gisselbrecht, Jan Cornelissen, Roberto Foa, Eulogio Conde, Johan Maertens, Michel Attal, Alessandro Rambaldi, Charles Crawley, et al.
Autologous stem cell transplantation (ASCT) consolidation remains the treatment of choice for patients with relapsed diffuse large B cell lymphoma. The impact of rituximab combined with chemotherapy in either first- or second-line therapy on the ultimate results of ASCT remains to be determined, however. This study was designed to evaluate the benefit of ASCT in patients achieving a second complete remission after salvage chemotherapy by ...

Allogeneic stem cell transplantation as salvage therapy in patients with diffuse large B-cell non-Hodgkin's lymphoma relapsing after an autologous stem cell transplantation. An analysis of the EBMT Registry KU Leuven

R van Kampen, C Canals, H Schouten, A Nagler, K Thomson, K Ward, JP Vernant, A Buzyn, J Maertens, JJ Luan, et al.
PURPOSE: To analyze the outcome, including nonrelapse mortality (NRM), relapse rate (RR), progression-free survival (PFS), and overall survival (OS), of patients with diffuse large B-cell non-Hodgkin's lymphoma (DLBCL) relapsed after an autologous stem-cell transplantation (ASCT) and treated with an allogeneic stem-cell transplantation (allo-SCT). PATIENTS AND METHODS: The European Group for Blood and Marrow Transplantation database was scanned ...