CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR BINDERS FOR TARGETED PROTEIN DEGRADATION Vlaams Instituut voor Biotechnologie
The present invention relates to protein binding agents specifically binding the human cation-independent mannose-6-phosphate receptor (CI-M6PR), more specifically polypeptide agents comprising an immunoglobulin single variable domain (ISVD) specifically binding CI-M6PR at nano- to picomolar affinity, fused to further protein binding agents specifically binding extracellularly-accessible protein targets, such as membrane proteins, extracellular or secreted proteins. More specifically said CI-M6PR-specific ISVD recognizes CI-M6PR N-terminal domains 1, 2 and / or 3, thereby providing for means ...