Publicaties
Functional characterization of in vivo effector CD4+ and CD8+ T cell responses in acute Toxoplasmosis : an interplay of IFN-gamma and cytolytic T cells. Vrije Universiteit Brussel
infected subjects are protected against secondary infection during pregnancy. CocktailDNAvaccines have
been shown to provide high resistance to parasite challenge, and latently infected mice are protected
against acute disease. In order to characterize the associated Th1 cellular immune responses in vivo, we
used H2-Kk ...
Activation of myelin reactive T cells in multiple sclerosis: A possible role for T cell degeneracy? Universiteit Hasselt
Induction of cytomegalovirus-specific T cell responses in healthy volunteers and allogeneic stem cell recipients using vaccination with messenger RNA-transfected dendritic cells Vrije Universiteit Brussel Universiteit Antwerpen
BACKGROUND: Infection with human cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ and hematopoietic stem cell transplant (HSCT) recipients.
METHODS: The present study explored the safety, feasibility, and immunogenicity of CMV pp65 messenger RNA-loaded autologous monocyte-derived dendritic cells (DC) as a cellular vaccine for active immunization in healthy volunteers and allogeneic HSCT recipients. ...
Tolerogenic dendritic cells induce apoptosis-independent T cell hyporesponsiveness of SARS-CoV-2-specific T cells in an antigen-specific manner Universiteit Antwerpen
Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells Universiteit Gent
An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells Vrije Universiteit Brussel
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active variant of toll-like receptor 4 and the co-stimulatory molecule CD70, enables an antibacterial transcriptional program. Besides, we further show that the DCs are redirected into an antiviral ...
Contribution of regulatory t cells and effector t cell deletion in tolerance induction by costimulation blockade KU Leuven
Helios plus Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell response. The co-expression of FoxP3 and Helios transcription factors, has been described for identification of highly suppressive Tregs. The ...