Publicaties
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Stereotactic Body Radiotherapy and Immunotherapy for Older Patients with Oligometastases: A Proposed Paradigm by the International Geriatric Radiotherapy Group Vrije Universiteit Brussel
The standard of care for metastatic disease is systemic therapy. A unique subset of patients with limited metastatic disease defined as distant involvement of five anatomic sites or less (oligometastases) have a better chance of remission or improved survival and may benefit from local treatments such as surgery or stereotactic body radiotherapy (SBRT). However, to prevent further spread of disease, systemic treatment such as chemotherapy, ...
Phase II study of stereotactic body radiotherapy to primary tumor and metastatic locations in oligometastatic nonsmall-cell lung cancer patients Vrije Universiteit Brussel
BACKGROUND:
Stereotactic body radiotherapy (SBRT) has emerged as a treatment modality in patients presenting with oligometastatic nonsmall-cell lung cancer (NSCLC). SBRT is used as a local consolidative treatment to metastatic disease sites. The majority of patients included in SBRT trials for oligometastatic NSCLC have controlled primary tumors and brain metastases.
PATIENTS AND METHODS:
Oligometastatic ...
Stereotactic body radiotherapy (SBRT) has emerged as a treatment modality in patients presenting with oligometastatic nonsmall-cell lung cancer (NSCLC). SBRT is used as a local consolidative treatment to metastatic disease sites. The majority of patients included in SBRT trials for oligometastatic NSCLC have controlled primary tumors and brain metastases.
PATIENTS AND METHODS:
Oligometastatic ...
Improving precision in Stereotactic Body Radiotherapy for oligometastatic disease. Vrije Universiteit Brussel
In the last decade, Stereotactic Body Radiotherapy (SBRT) is being increasingly used for the treatment of oligometastatic disease. Two previous trials in our center demonstrated a high survival and a low toxicity, but the local control was deemed suboptimal. The first part of this thesis therefore describes a study to uncover the root cause of this issue, by analyzing the recurrences in comparison with the irradiated volume. The gained knowledge ...
A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma : evaluation of clinical and immunologic response Universiteit Gent
Randomized phase 1 trial of pembrolizumab with sequential versus concomitant stereotactic body radiotherapy in metastatic urothelial carcinoma Universiteit Gent
Progression-free survival following stereotactic body radiotherapy for oligometastatic prostate cancer treatment-naive recurrence : a multi-institutional analysis Universiteit Gent
Repeated stereotactic body radiotherapy for oligometastatic prostate cancer recurrence Universiteit Gent
Stereotactic body radiotherapy for primary prostate cancer Universiteit Gent
Prostate cancer is the most common non-cutaneous cancer in males. There are a number of options for patients with localized early stage disease, including active surveillance for low-risk disease, surgery, brachytherapy, and external beam radiotherapy. Increasingly, external beam radiotherapy, in the form of dose-escalated and moderately hypofractionated regimens, is being utilized in prostate cancer, with randomized evidence to support their ...