Stabilisation and controlled release of silibinin from pH responsive shellac colloidal particles Universiteit Gent
Orally administered bioactive compounds have to survive acidic environs (pH 1.2) of the stomach and reach the small intestine (pH 6.8-7.4), which is the main site of absorption in the gastrointestinal tract. Hence, it is desired to have a delivery system which can protect the active molecules from degradation in acidic pH but release them in the small intestine. This objective was achieved in the present work by formulating stable shellac ...