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Oxidative post-translational modifications of cysteine residues in plant signal transduction Universiteit Gent Vrije Universiteit Brussel
Super-resolution fluorescence microscopy based techniques for the study of signal transduction KU Leuven
To transmit a message from one to another, correct communication is crucial. To obtain correct communication, it is important that both transmitter and receiver of the signal are present at the correct time at the correct location. In a cell this communication is taken care of by signal transduction pathways. They consist of a highly branched network of proteins and messenger molecules, integrating signals to a final work plan guiding the cell ...
Insulin-like Growth Factor-I Receptor Signal Transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) Pathway Vrije Universiteit Brussel
The insulin-like growth factor IGF-I is an important fetal and post-natal growth factor which is also involved in tissue homeostasis via regulation of proliferation, differentiation and cell survival. In order to understand the role of IGF-I in the pathophysiology of a variety of disorders, including growth disorders, cancer and neurodegenerative diseases, a detailed knowledge of IGF-I signal transduction is required. This knowledge may also ...
Electrical impedance spectroscopy and 3D cell cultures as emerging technologies for studying signal transduction pathways: the curious case of cathelicidins KU Leuven
This doctoral dissertation has two important parts. The first part covers experiments on elucidating the signal transduction pathways of recently discovered candidate bioactive peptides. The second part introduces 3D cell culture systems and expands on differential gene expression between 2D and 3D cell cultures using RNA-sequencing.Bioactive peptides perform countless functions in multicellular organisms as key players in cell-cell ...
Ethylene signal transduction during climacteric tomato fruit ripening KU Leuven
Tomato (Solanum lycopersicum L.) is a crop of high economic and nutritional value produced worldwide. Besides having a high number of vitamins and minerals, tomato fruit is rich in other bioactive components including carotenoids and phenolic compounds. In addition, it is an ideal model system to study fleshy fruit development and ripening thanks to its relative short life cycle, its small genome size and the availability of a large selection of ...
ALISSA: an automated live-cell imaging system for signal transduction analyses KU Leuven
Probe photobleaching and a specimen's sensitivity to phototoxicity severely limit the number of possible excitation cycles in time-lapse fluorescent microscopy experiments. Consequently, when a study of cellular processes requires measurements over hours or days, temporal resolution is limited, and spontaneous or rapid events may be missed, thus limiting conclusions about transduction events. We have developed ALISSA, a design framework and ...
PD1 signal transduction pathways in T cells Vrije Universiteit Brussel
The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on ...
Characterization of Sch9-dependent signal transduction in Saccharomyces cerevisiae. KU Leuven
De mogelijkheid om het metabolisme aan te passen aan veranderingen in de omgeving is van essentieel belang voor elk organisme. Bij zoogdieren zorgen groeifac toren en hormonen via complexe signaaltransductiecascades voor een strikte regulatie van h et metabolisme. Deze signaaltransductiewegen zijn sterk geconserveerd in de bakkersgist Sacch aromyces cerevisiae, waar de rol van de hormonen en de groeifactoren wordt overgenomen door n utriënten. ...
Glucose Sensing and Signal Transduction in Saccharomyces cerevisiae KU Leuven
Cells of the yeast Saccharomyces cerevisiae have an exquisite preference for high concentrations of glucose compared to other sugars or carbon sources. The likely explanation is that glucose is the best fermentable sugar, i.e., the sugar that allows the yeast to accumulate most rapidly high levels of ethanol, which are strongly inhibitory to competing microorganisms. To accomplish rapid fermentation of glucose, S. cerevisiae has evolved multiple ...