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Comparison of Patient-Oriented Eczema Measure and Patient-Oriented Scoring Atopic Dermatitis vs Eczema Area and Severity Index and other measures of atopic dermatitis Vrije Universiteit Brussel

Muhammad Yousaf, Sherief Janmohamed, Rajeev Chavda, Sylvie Gabriel, Kevin R Patel

BACKGROUND: Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with atopic dermatitis (AD). Even less is known about how PO-SCORAD performs compared with the Patient-Oriented Eczema Measure (POEM).

OBJECTIVE: To examine the measurement properties of PO-SCORAD and compare them with those of POEM.

METHODS: A prospective dermatology practice-based study of 291 ...

Hospital financing of ischaemic stroke: determinants of funding and usefulness of DRG subcategories based on severity of illness KU Leuven

Vincent Thijs
BACKGROUND: Several Western and Arab countries, as well as over 30 States in the US are using the "All-Patient Refined Diagnosis-Related Groups" (APR-DRGs) with four severity-of-illness (SOI) subcategories as a model for hospital funding. The aim of this study is to verify whether this is an adequate model for funding stroke hospital admissions, and to explore which risk factors and complications may influence the amount of funding. METHODS: A ...

Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment Universiteit Hasselt

Daniek A. M. Meijs, Bas C. T. van Bussel, Bjorn STESSEL, Jannet Mehagnoul-Schipper, Anisa Hana, Clarissa I. E. Scheeren, Sanne A. E. Peters, Walther N. K. A. van Mook, Iwan C. C. van der Horst, Gernot Marx, et al.
Although male Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients have higher Intensive Care Unit (ICU) admission rates and a worse disease course, a comprehensive analysis of female and male ICU survival and underlying factors such as comorbidities, risk factors, and/or anti-infection/inflammatory therapy administration is currently lacking. Therefore, we investigated the association between sex and ICU survival, adjusting for ...

The effect of levetiracetam on tremor severity and functionality in patients with multiple sclerosis. Universiteit Hasselt

Peter FEYS, M D'Hooge, G Nagels, W Helsen
BACKGROUND: Multiple sclerosis (MS) intention tremor is a disabling symptom, which is difficult to treat. OBJECTIVES: To investigate the effects of levetiracetam, an antiepileptic drug, on tremor severity and related functionality in MS. METHODS: A randomized, double-blind, placebo-controlled, cross-over study examined the effects of 6 weeks of oral levetiracetam administration (starting dose=250 mg/day, maximal dose=2000 mg/day) in 18 MS ...

Detection of excess influenza severity: associating respiratory hospitalization and mortality data with reports of influenza-like illness by primary care physicians Instituut voor Tropische Geneeskunde

Cees C van den Wijngaard, Liselotte Chi van Asten, Adam Meijer, Wilfrid van Pelt, Nico J D Nagelkerke, Gé A Donker, Marianne van der Sande, Marion P G Koopmans

OBJECTIVES: We explored whether excesses in influenza severity can be detected by combining respiratory syndromic hospital and mortality data with data on influenza-like illness (ILI) cases obtained from general practitioners.

METHODS: To identify excesses in the severity of influenza infections in the population of the Netherlands between 1999 and 2005, we looked for increases in influenza-associated hospitalizations and mortality ...

A real-world study of the longitudinal course of adult atopic dermatitis severity in clinical practice Vrije Universiteit Brussel

Mindy R Hong, Muhammad Yousaf, Rajeev Chavda, Sylvie Gabriel, Sherief Janmohamed

BACKGROUND: Little is known about the longitudinal course of adult atopic dermatitis (AD) lesional severity and extent in clinical practice.

OBJECTIVE: To determine the longitudinal course of AD in clinical practice.

METHODS: A prospective, dermatology practice-based study was performed (n = 400). Patients were assessed at baseline and approximately 6, 12, 18, and 24 months by eczema area and severity index (EASI) and ...

Association of severity of menstrual dysfunction with cardiometabolic risk markers among women with polycystic ovary syndrome Vrije Universiteit Brussel

Jie Yang, Christophe Blockeel, Xiaoyan Tian, Yaqi Cao, Ling Deng, Xianli Zhou, Jinying Xie

INTRODUCTION: Polycystic ovary syndrome (PCOS) is associated with a wide range of unfavorable cardiometabolic risk factors, including obesity, hypertension, insulin resistance, impaired glucose metabolism, dyslipidemia, and metabolic syndrome. Compared with women with regular menstrual cycles, women with a history of irregular menstrual periods have an increased unfavorable cardiometabolic risk. Recently, the association between the severity ...

In Silico Analysis of the Molecular-Level Impact of SMPD1 Variants on Niemann-Pick Disease Severity Vrije Universiteit Brussel

François Ancien, Fabrizio Pucci, Marianne Rooman

Sphingomyelin phosphodiesterase (SMPD1) is a key enzyme in the sphingolipid metabolism. Genetic SMPD1 variants have been related to the Niemann-Pick lysosomal storage disorder, which has different degrees of phenotypic severity ranging from severe symptomatology involving the central nervous system (type A) to milder ones (type B). They have also been linked to neurodegenerative disorders such as Parkinson and Alzheimer. In this paper, we ...

Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities Vrije Universiteit Brussel

Sofia Ajeganova, Maria L E Andersson, Ingiäld Hafström

OBJECTIVE: To determine the association of obesity, defined as a body mass index (BMI) ≥30 or ≥28 kg/m(2) or by waist circumference (WC), with disease activity and severity, as well as its relationship to comorbidities in rheumatoid arthritis (RA).

METHODS: The study population comprised 1,596 patients with early RA (mean ± SD age 55.6 ± 14.6 years, 67.8% women) who had been included in the Better Anti-Rheumatic Farmacotherapy ...

Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis Vrije Universiteit Brussel

Muhammad Yousaf, Sherief Janmohamed, Rajeev Chavda, S. Gabriel, Kevin R Patel

BACKGROUND: Multiple atopic dermatitis (AD) severity scales exist, with no gold standard for use in clinical practice.

OBJECTIVES: To determine the measurement properties of the Rajka-Langeland score and compare it with other clinician-reported outcomes in adults and children with AD.

METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 427).

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