Publicaties
Microfluidic Device for High-Throughput Production of Monodisperse Droplets Vrije Universiteit Brussel
Discrimination of diesel fuels marketed in Morocco using FTIR, GC-MS analysis and chemometrics methods Vrije Universiteit Brussel
The purpose of this study was to perform a discrimination and classification of diesel samples from the four major suppliers of petroleum products in Morocco using Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography coupled with Mass Spectrometry (GC-MS) and chemometrics tools. Eighty diesel samples were collected from different gas stations owned by the four biggest brands in the Moroccan market. Principal Component Analysis ...
Xanthones and Cancer Vrije Universiteit Brussel
Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further ...
A new potential anti-cancer beta-carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness Vrije Universiteit Brussel
Gliomas remain highly fatal due to their high resistance to current therapies. Deregulation of protein synthesis contributes to cancer onset and progression and is a source of rising interest for new drugs. CM16, a harmine derivative with predicted high blood-brain barrier penetration, exerts antiproliferative effects partly through translation inhibition. We evaluated herein how CM16 alters the proteome of glioma cells. The analysis of the ...
Recent advances in untargeted and targeted approaches applied in herbal-extracts and essential-oils fingerprinting - A review Vrije Universiteit Brussel
Herbal extracts and essential oils have been used over the centuries for their dietary, cosmetic and therapeutic properties. Quality control is needed to guarantee the safety and quality of these consumables. In this regard, fingerprinting techniques are important for inspection of the authenticity and for quality control. Analytical fingerprinting techniques provide signals related to the composition of a matrix (oil, plant extract, food…). ...
HPLC-DAD/TOF-MS Chemical Compounds Analysis and Evaluation of Antibacterial Activity of Aristolochia longa Root Extracts Vrije Universiteit Brussel
The present study aimed to determine the phenolic compounds of Aristolochia longa root extracts and to evaluate their antibacterial activities on multiresistant strains. Phytochemical analysis revealed the presence of flavonoids, tannins, terpenoids, and alkaloids. The HPLC-DAD analysis of A. longa extracts showed the presence of several major bioactive compounds such as ferulic acid, 4-hydroxycinnamic acid, citric acid, and quinic acid. The ...
Analytical techniques for metabolomic studies Vrije Universiteit Brussel
Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage of the metabolome is challenging because of the broad range of physicochemical properties of the small molecules. To study the compounds of interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for a given technique is influenced by the sample matrix, the ...
The influence of air and temperature on the reaction mechanism and molecular structure of Fe-silicate inorganic polymers Vrije Universiteit Brussel KU Leuven
Fe-rich inorganic polymers are rising in importance because of their low CO 2 emissions during production and their potential in upcycling metallurgical residues. Here, the oxidation of Fe during formation of the binder from 0.4CaO-1.2FeO x-SiO 2 slag is investigated in more detail using 57Fe Mössbauer spectroscopy. It was shown that the oxidation at early stages is not influenced by (O 2 in the) air. Later, the quadrupole split Fe 2+ state ...
In vivo anti-inflammatory response and bioactive compounds’ profile of polyphenolic extracts from edible Argan oil (Argania spinosa L.), obtained by two extraction methods Vrije Universiteit Brussel
The present work examined and assessed the in vivo anti-inflammatory effect of polyphenolic extracts from Moroccan edible Argan oils (Argania spinosa L.), extracted by two extraction processes: Hand pressing and mechanical pressing. Chemical properties, such as acidity, peroxide index, ultraviolet indices, total polyphenols composition, fatty acid composition, tocopherol composition, phenolic profiling, and sterol composition were studied. ...