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Comparison of different phenotypic assays for teh detection of extended-sprectrum beta-lactamase production by inducible AmpC-producing Gram-negative bacilli KU Leuven
Routine detection of extended-spectrum β-lactamase (ESBL) production by AmpC-producing Enterobacteriaceae in microbiology laboratories is still a problem. The aim of this study was to compare the performance of four different phenotypic ESBL confirmation assays within this group of Enterobacteriaceae. A total of 83 AmpC-inducible Enterobacteriaceae were included in this study (58 clinical isolates with presumptive ESBL production and 25 ...
Prevalence and distribution of beta-lactamase coding genes in third-generation cephalosporin-resistant Enterobacteriaceae from bloodstream infections in Cambodia Instituut voor Tropische Geneeskunde KU Leuven Universiteit Antwerpen
Resistance to third-generation cephalosporins in Gram-negative bacteria is emerging in Asia. We report the prevalence and distribution of extended-spectrum beta-lactamase (ESBL), AmpC beta-lactamase and carbapenemase-coding genes in cefotaxime-resistant Enterobacteriaceae isolates from bloodstream infections (BSI) in Cambodia. All Enterobacteriaceae isolated from BSI in adult patients at Sihanouk Hospital Centre of HOPE, Phnom Penh, Cambodia ...
Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance Universiteit Antwerpen
Antibiotic-induced perturbation of the human gut flora is expected to play an important role in mediating the relationship between antibiotic use and the population prevalence of antibiotic resistance in bacteria, but little is known about how antibiotics affect within-host resistance dynamics. Here we develop a data-driven model of the within-host dynamics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae. We use ...
Nosocomial acquisition of methicillin-resistant **Staphyloccocus aureus** (MRSA) and extended-spectrum beta-lactamase (ESBL) **Enterobacteriaceae** in hospitalised patients: a prospective multicenter study Universiteit Antwerpen
Background: The risk of acquisition of antibiotic resistant-bacteria during or shortly after antibiotic therapy is still unclear and it is often confounded by scarce data on antibiotic usage. Primary objective of the study is to compare rates of acquisition of methicillin-resistant Staphylococcus aureus and extended spectrum beta-lactamase-producing Enterobacteriaceae in hospitalised patients, after starting antibiotic therapy. Methods/Design: ...
High abundance and diversity of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in faeces and tonsils of pigs at slaughter Universiteit Gent
Catheter-related phlebitis in calves associated with broad-spectrum beta-lactamase producting Escherichia coli Universiteit Gent
OXA-427, a new plasmid-borne carbapenem-hydrolysing class D beta-lactamase in Enterobacteriaceae KU Leuven
OBJECTIVES: To describe a novel plasmid-borne class D carbapenemase (CHDL) named OXA-427 identified in several Enterobacteriaceae clinical isolates from nine patients in one Belgian hospital. METHODS: OXA-427-producing isolates were analysed by an electrochemical imipenem hydrolysis method (BYG Carba test), Carba NP test, conventional phenotypic assays and by molecular methods (PCR, whole sequencing of the OXA-427-encoding plasmid and cloning). ...
Empirische antibioticatherapie in tijden van „extended spectrum” bètalactamaseproducerende Enterobacteriaceae KU Leuven
Empirical antibiotic therapy in the face of rising ESBL incidence The worldwide increase in extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae is evident in Belgium as well, with approximately 7% of E. coli and 16% of K. pneumoniae clinical strains showing non-sensitivity to third generation cephalosporins. On the other hand, unrelentless use of carbapenem antibiotics will lead to selection of carbapenemaseproducing ...
Salmonella enterica serovar Typhi producing CTX-M-15 extended spectrum β-lactamase in the Democratic Republic of the Congo Universiteit Antwerpen KU Leuven Instituut voor Tropische Geneeskunde
We report a typhoid fever case with a Salmonella enterica serovar Typhi isolate showing extended spectrum beta-lactamase (ESBL) production in the Democratic Republic of the Congo. Whole genome sequencing revealed that the strain carried a plasmid-mediated CTX-M-15 ESBL gene and did not belong to the dominant H58 Salmonella Typhi clade.