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Four-year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique Instituut voor Tropische Geneeskunde

Tom Decroo, Olivier Koole, Daniel Remartinez, Natacha dos Santos, Sergio Dezembro, Mariano Jofrisse, Freya Rasschaert, Marc Biot

OBJECTIVE: Community ART groups (CAG), peer support groups involved in community ART distribution and mutual psychosocial support, were piloted to respond to staggering antiretroviral treatment (ART) attrition in Mozambique. To understand the impact of CAG on long-term retention, we estimated mortality and lost-to-follow-up (LTFU) rates and assessed predictors for attrition.

METHODS: Retrospective cohort study. Kaplan-Meier techniques ...

Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes : a narrative review with emphasis on data from Europe Universiteit Gent

Ioannis Kyrou, [missing] on behalf of the Feel4Diabetes-study Group, Constantine Tsigos, Christina Mavrogianni, Greet Cardon, Vicky Van Stappen, Julie Latomme, Jemina Kivelä, Katja Wikström, Kaloyan Tsochev, et al.
Background: Type 2 diabetes mellitus (T2DM) comprises the vast majority of all diabetes cases in adults, with alarmingly increasing prevalence over the past few decades worldwide. A particularly heavy healthcare burden of diabetes is noted in Europe, where 8.8% of the population aged 20–79 years is estimated to have diabetes according to the International Diabetes Federation. Multiple risk factors are implicated in the pathogenesis of T2DM with ...

Food groups and risk of colorectal cancer Universiteit Gent

Lukas Schwingshackl, Carolina Schwedhelm, Georg Hoffmann, Sven Knüppel, Anne Laurre Preterre, Khalid Iqbal, Angela Bechthold, Stefaan De Henauw, Nathalie Michels, Brecht Devleesschauwer, et al.
The aim of this systematic review and meta-analysis was to summarize the evidence on the relationship between intake of 12 major food groups, including whole grains, refined grains, vegetables, fruit, nuts, legumes, eggs, dairy, fish, red meat, processed meat and sugar-sweetened beverages with risk of colorectal cancer (CRC). We conducted a systematic search in PubMed and Embase for prospective studies investigating the association between these ...

Clear-cell Renal Cell Carcinoma: Molecular Characterization of IMDC Risk Groups and Sarcomatoid Tumors KU Leuven

Annelies Verbiest, Annouschka Laenen, Patrick Schöffski, Maarten Albersen, Agnieszka Wozniak, Benoit Beuselinck
INTRODUCTION: Recent trials have suggested predictive biomarkers in advanced clear-cell renal cell carcinoma (accRCC): International Metastatic RCC Database Consortium (IMDC) good risk or angiogenic gene signature for sunitinib and IMDC intermediate/poor risk for ipilimumab-nivolumab and T-effector cell signature or sarcomatoid dedifferentiation for atezolizumab-bevacizumab. We hypothesized that earlier described molecular subtypes, ccrcc1 to ...

Exploring Risk Groups Workplace Bullying with Categorical Data KU Leuven

Guy Notelaers, Elfi Baillien, Hans De Witte
In this study, we first explore whether different exposure groups of workplace bullying exist, employing a large, heterogeneous sample. The results show six different exposure groups: almost 30.5% is not bullied since they report hardly any negative act at work at all, 27.2% face some limited work criticism, 20.8% face limited negative encounters, 8.3% is occasionally bullied, 9.5% are predominately work related bullied, and a total of 3.6% can ...

Impact of the International Prognostic Scoring System cytogenetic risk groups on the outcome of patients with primary myelodysplastic syndromes undergoing allogeneic stem cell transplantation from human leukocyte antigen-identical siblings: a retrospectiv KU Leuven

Johan Maertens
Acquired chromosomal abnormalities are important prognostic factors in patients with myelodysplastic syndromes treated with supportive care and with disease-modifying therapeutic interventions, including allogeneic hematopoietic stem cell transplantation. To assess the prognostic impact of cytogenetic characteristics after hematopoietic stem cell transplantation accurately, we investigated a homogeneous group of 523 patients with primary ...

Quantifying rates of HIV-1 flow between risk groups and geographic locations in Kenya: A country-wide phylogenetic study KU Leuven

Guy Baele, Philippe Lemey
In Kenya, HIV-1 key populations including men having sex with men (MSM), people who inject drugs (PWID) and female sex workers (FSW) are thought to significantly contribute to HIV-1 transmission in the wider, mostly heterosexual (HET) HIV-1 transmission network. However, clear data on HIV-1 transmission dynamics within and between these groups are limited. We aimed to empirically quantify rates of HIV-1 flow between key populations and the HET ...

ScreenTB: a tool for prioritising risk groups and selecting algorithms for screening for active tuberculosis Instituut voor Tropische Geneeskunde

C. R. Miller, Ellen M.H. Mitchell, N. Nishikiori, A. Zwerling, K. Lonnroth

SETTING AND OBJECTIVES: There is an urgent need to improve tuberculosis (TB) case detection globally. This would require greater focus on the implementation of TB screening programs. However, to be productive, cost-effective, and ethical, TB screening efforts should be tailored to their local context, targeted to the populations most likely to benefit and utilizing diagnostic tools with sufficient accuracy.

DESIGN AND RESULTS: We have ...

External Validation of the Ovarian-Adnexal Reporting and Data System (O-RADS) Lexicon and the International Ovarian Tumor Analysis 2-Step Strategy to Stratify Ovarian Tumors Into O-RADS Risk Groups KU Leuven

Stefan Timmerman, Jolien Ceusters, Thomas Holland Bourne, Ben Van Calster, Wouter Froyman
IMPORTANCE: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy. OBJECTIVE: To investigate the diagnostic performance of the O-RADS lexicon and the IOTA 2-step ...

Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome KU Leuven

Tom Adriaenssens
Postmortem studies reported plaque erosion is frequent in young women. Recent in vivo studies failed to show age and sex differences in the plaque erosion prevalence. The aim of this study was to investigate the prevalence of plaque erosion by age and sex among acute coronary syndromes (ACS) patients. From 1699 ACS patients, 1083 with plaque erosion or rupture were analyzed. Patients were categorized as 5 age groups (≤ 50, 51-60, 61-70, ...