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Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance gene-1 polymorphisms in the Democratic Republic of Congo and Uganda Universiteit Antwerpen

Vito Baraka, Hypolite Muhindo Mavoko, Carolyn Nabasumba, Filbert Francis, Pascal Lutumba, Michael Alifrangis, Jean-Pierre Van geertruyden
Background The emergence of resistance against artemisinin combination treatment is a major concern for malaria control. ACTs are recommended as the rescue treatment, however, there is limited evidence as to whether treatment and re-treatment with ACTs select for drug-resistant P. falciparum parasites. Thus, the purpose of the present study is to investigate the impact of (re-) treatment using artesunate-amodiaquine (ASAQ) and ...

Efficacy and Safety of Tofacitinib Re-treatment for Ulcerative Colitis After Treatment Interruption: Results from the OCTAVE Clinical Trials KU Leuven

Séverine Vermeire
BACKGROUND AND AIMS: Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. Here, we evaluate the efficacy and safety of tofacitinib re-treatment following treatment interruption in patients with ulcerative colitis. METHODS: Here, patients with clinical response to tofacitinib 10 mg b.d. induction therapy were randomised to receive placebo in OCTAVE Sustain. Those experiencing treatment failure ...

Treatment of pathophysiologic propagation outside of the pulmonary veins in retreatment of atrial fibrillation patients Vrije Universiteit Brussel

Timothy R Betts, Wilson W Good, Lea Melki, Andreas Metzner, Andrew Grace, Atul Verma, Stephen Murray, Simon James, Tom Wong, Lucas V A Boersma, et al.

AIMS: RECOVER AF evaluated the performance of whole-chamber non-contact charge-density mapping to guide the ablation of non-pulmonary vein (PV) targets in persistent atrial fibrillation (AF) patients following either a first or second failed procedure.

METHODS AND RESULTS: RECOVER AF was a prospective, non-randomized trial that enrolled patients scheduled for a first or second ablation retreatment for recurrent AF. The PVs were ...

Efficacy and safety of re-treatment with the same artemisinin-based combination treatment (ACT) compared with an alternative ACT and quinine plus clindamycin after failure of first-line recommended ACT (QUINACT): a bicentre, open-label, phase 3, randomise Instituut voor Tropische Geneeskunde Universiteit Antwerpen

Hypolite Muhindo Mavoko, Carolyn Nabasumba, Raquel Inocêncio da Luz, Halidou Tinto, D'Alessandro, Andrew Kambugu, Vito Baraka, Anna Rosanas-Urgell, Pascal Lutumba, Jean-Pierre Van Geertruyden, et al.

BACKGROUND: Quinine or alternative artemisinin-based combination treatment (ACT) is the recommended rescue treatment for uncomplicated malaria. However, patients are often re-treated with the same ACT though it is unclear whether this is the most suitable approach. We assessed the efficacy and safety of re-treating malaria patients with uncomplicated failures with the same ACT used for the primary episode, compared with other rescue ...

Effect of amoxicillin dose and treatment duration on the need for antibiotic re-treatment in children with community-acquired pneumonia Universiteit Antwerpen

Julia A. Bielicki, Wolfgang Stöhr, Sam Barratt, David Dunn, Nishdha Naufal, Damian Roland, Kate Sturgeon, Adam Finn, Juan Pablo Rodriguez Ruiz, Surbhi Malhotra, et al.
This randomized clinical trial compares the need for re-treatment of respiratory infection following hospitalization for community-acquired pneumonia among children receiving amoxicillin at high doses vs low doses and at 3-days vs 7-days duration. Question For children with community-acquired pneumonia discharged from an emergency department, observational unit, or inpatient ward (within 48 hours), is subsequent outpatient treatment with oral ...

Membrane Fouling and Rejection of Organics during Algae-Laden Water Treatment Using Ultrafiltration: A Comparison between in Situ Pretreatment with Fe(II)/Persulfate and Ozone KU Leuven

Bin Liu, Bart Van der Bruggen
In this study, in situ pretreatments with ozone and Fe(II)/persulfate were employed to suppress membrane fouling during the filtration of algae-laden water and to improve the rejection of metabolites. Both ozonation and Fe(II)/persulfate pretreatments negatively impacted the cell integrity, especially ozonation. Fe(II)/persulfate pretreatment improved the removal of dissolved organic carbon and microcystin-LR, but ozonation resulted in a ...

Gamma evaluation with Octavius 4D phantom for pretreatment of modern radiotherapy treatment techniques Universiteit Gent

Raju Prasad Srivastava, K. Basta, K. Thevissen, S. Junius, K. Vandeputte, Carlos De Wagter
Purpose: In modern radiotherapy techniques such as intensity-modulated radiation therapy (IMRT) and volume modulated arc therapy (VMAT), the quality assurance (QA) process is vital. The goal of the study was to verify the treatment planning dose delivered during delivery of complex treatment plans. The QA standard is to perform patient-specific comparisons between planned doses and doses measured in a phantom. Materials and Methods: Ninety-five ...