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Band 3-mediated Plasmodium vivax invasion is associated with transcriptional variation in PvTRAg genes Instituut voor Tropische Geneeskunde Universiteit Antwerpen

Katlijn De Meulenaere, Surendra Prajapati, Elizabeth Villasis, Bart Cuypers, Eline Kattenberg, Bernadine Kasian, Moses Laman, Leanne J Robinson, Dionicia Gamboa, Kris Laukens, et al.

The Plasmodium vivax reticulocyte invasion process is still poorly understood, with only a few receptor-ligand interactions identified to date. Individuals with the Southeast Asian ovalocytosis (SAO) phenotype have a deletion in the band 3 protein on the surface of erythrocytes, and are reported to have a lower incidence of clinical P. vivax malaria. Based on this observation, band 3 has been put forward as a receptor for P. vivax invasion, ...

von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome Instituut voor Tropische Geneeskunde KU Leuven

Sirima Kraisin, Sebastien Verhenne, Thy, Kimberly Martinod, Claudia Tersteeg, Nele Vandeputte, Hans Deckmyn, Karen Vanhoorelbeke, Philippe E. Van den Steen, Simon F De Meyer, et al.

Background: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a lethal complication of severe malaria, characterized by marked pulmonary inflammation. Patient studies have suggested a link between von Willebrand factor (VWF) and malaria severity.

Objectives: To investigate the role of VWF in the pathogenesis of experimental MA-ARDS.

Methods: Plasmodium berghei NK65-E (PbNK65) parasites were injected in Vwf+/+ ...