Publicaties
Gekozen filters:
Gekozen filters:
Correlations between measures of ALS respiratory function: is there an alternative to FVC? KU Leuven
Background: An ongoing longitudinal study in six European sites includes a 3-monthly assessment of forced vital capacity (FVC), slow vital capacity (SVC), peak cough flow (PCF), and Sniff nasal inspiratory pressure (SNIP). The aim of this interim analysis was to assess the potential for SNIP to be a surrogate for aerosol generating procedures given COVID-19 related restrictions. Methods: This was a prospective observational study. Patients ...
Functional respiratory imaging to assess the interaction between systemic roflumilast and inhaled ICS/LABA/LAMA Universiteit Antwerpen
Background: Patients with COPD show a significant reduction of the lobar hyperinflation at the functional residual capacity level in the patients who improved >120 mL in forced expiratory volume in 1 second (FEV1) after 6 months of treatment with roflumilast in addition to inhaled corticosteroids (ICSs)/long-acting beta-2 agonists (LABAs)/long-acting muscarinic antagonists (LAMAs). Methods: Functional respiratory imaging was used to quantify ...
Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis Universiteit Antwerpen
Background Functional Respiratory Imaging (FRI) combines HRCT scans with computational fluid dynamics to provide objective and quantitative information about lung structure and function. FRI has proven its value in pulmonary diseases such as COPD and asthma, but limited studies have focused on cystic fibrosis (CF). This study aims to investigate the relation of multiple FRI parameters to validated imaging parameters and classical respiratory ...
Estimation of respiratory phases during proton radiotherapy from a 4D-CT and Prompt gamma detection profiles KU Leuven
Proton radiotherapy has a potential to provide an effective cancer treatment while sparing greater volume of healthy tissue than the conventional X-ray based radiotherapy. However, in lungs this potential is hindered by motion due to breathing. An important quantity in treatment verification is the correlation between the respiratory phases (RP) and the timing of pencil beam scanning (PBS). In this note, we demonstrate how the RP can be ...
Mechanical Properties of the Respiratory System Derived From Morphologic Insight KU Leuven Universiteit Gent
This paper aims to provide the mechanical parameters of the respiratory airways (resistance, inertance, and compliance) from morphological insight, in order to facilitate the correlations of fractional-order models with pathologic changes. The approach consists of taking into account wall thickness, inner radius, tube length, and tissue structure for each airway level to combine them into a set of equations for modeling the pressure drop, flow, ...
Parameterisation of respiratory impedance in lung cancer patients from forced oscillation lung function test Universiteit Antwerpen Universiteit Gent
Objective: This study aims to analyze the contribution and application of forced oscillation technique (FOT) devices in lung cancer assessment. Two devices and corresponding methods can be feasible to distinguish among various degrees of lung tissue heterogeneity. Methods: The outcome respiratory impedance Z(rs) (in terms of resistance R-rs and reactance X-rs) is calculated for FOT and is interpreted in physiological terms by being fitted with a ...
Managing respiratory disease in finisher pigs: Combining quantitative assessments of clinical signs and the prevalence of lung lesions at slaughter KU Leuven
This study aimed to assess the relationship between quantitative assessments of clinical signs of respiratory disease (recorded manually and automatically) and the prevalence of lung lesions at slaughter to validate the use of both in the management of respiratory disease on farm. This was an observational study where pigs (n = 1573) were monitored from 25 ± 5.3 kg (week 12) to slaughter at 114 ± 15.4 kg (week 24). Pigs were housed in eight ...
Gammaherpesvirus BoHV-4 infects bovine respiratory epithelial cells mainly at the basolateral side Universiteit Gent
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that is widespread in cattle. However, only a few studies about the pathogenesis of BoHV-4 primary infection have been reported. In the present study, ex vivo models with bovine nasal and tracheal mucosa explants were used to study the cellular BoHV-4-host interactions. Infection was observed in nasal but not in tracheal epithelial cells. To find a possible correlation between the integrity and ...
Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis Universiteit Antwerpen KU Leuven
Probiotics, mainly lactic acid bacteria (LAB), are widely focused on gastrointestinal applications. However, recent microbiome studies indicate that LAB can be endogenous members of other human body sites such as the upper respiratory tract (URT). Interestingly, DNA-based microbiome research suggests an inverse correlation between the presence of LAB and the occurrence of potential pathogens, such as Moraxella catarrhalis, an important URT ...