Publicaties
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer Vrije Universiteit Brussel
Background & Aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and replication stress in PC. Methods: ...
Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells (Retracted article. See vol. 292, pg. 12786, 2017) KU Leuven
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity KU Leuven
Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction KU Leuven
Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells. Vlaams Instituut voor Biotechnologie KU Leuven
The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance Vrije Universiteit Brussel
Multiple myeloma (MM) is a hematologic cancer characterized by accumulation of malignant plasma cells in the bone marrow. To date, no definitive cure exists for MM and resistance to current treatments is one of the major challenges of this disease. The DNA helicase BLM, whose depletion or mutation causes the cancer-prone Bloom's syndrome (BS), is a central factor of DNA damage repair by homologous recombination (HR) and genomic stability ...