Publicaties
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Improving the intra-fraction update efficiency of a correlation model used for internal motion estimation during real-time tumor tracking for SBRT patients: Fast update or no update? Universiteit Antwerpen Vrije Universiteit Brussel KU Leuven
Background and purpose: For tumor tracking, a correlation model is used to estimate internal tumor position based on external surrogate motion. When patients experience an internal/external surrogate drift, an update of the correlation model is required to continue tumor tracking. In this study, the accuracy of the internal tumor position estimation for both the clinical available update at discrete points in time (rebuild) and an in-house ...
Treating patients with real-time tumor tracking using the Vero gimbaled linac system: Implementation and first review Universiteit Antwerpen KU Leuven Vrije Universiteit Brussel
Purpose: To report on the first clinical application of a real-time tumor tracking (RTTT) solution based on the Vero SBRT gimbaled linac system for treatment of moving tumors. Methods and materials: A first group of 10 SBRT patients diagnosed with NSCLC or oligometastatic disease in lung or liver was treated with the RTTT technique. The PTV volumes and OAR exposure were benchmarked against the widely used ITV approach. Based on data acquired ...
A comparison of two clinical correlation models used for real-time tumor tracking of semi-periodic motion: A focus on geometrical accuracy in lung and liver cancer patients Universiteit Antwerpen KU Leuven
Purpose: A head-to-head comparison of two clinical correlation models with a focus on geometrical accuracy for internal tumor motion estimation during real-time tumor tracking (RTTT). Methods and materials: Both the CyberKnife (CK) and the Vero systems perform RTTT with a correlation model that is able to describe hysteresis in the breathing motion. The CK dual-quadratic (DQ) model consists of two polynomial functions describing the trajectory ...
Comparison of two commercially available real-time tumor tracking solutions in a phantom study Vrije Universiteit Brussel
Feasibility of markerless tumor tracking by sequential dual-energy fluoroscopy on a clinical tumor tracking system Universiteit Antwerpen
Real-time tumor tracking (RTTT) through adaptation of the treatment beam has been reported to significantly reduce the treatment uncertainties related to respiratory induced motion in thoracic and abdominal tumors. However, the only two systems clinically available that are capable of performing this type of RTTT, both rely on implanted fiducials for accurate target localization on kV images, for the majority of lesions. The use of such ...
Geometric accuracy of a novel gimbals based radiation therapy tumor tracking system. Vrije Universiteit Brussel
PURPOSE: VERO is a novel platform for image guided stereotactic body radiotherapy. Orthogonal gimbals hold the linac-MLC assembly allowing real-time moving tumor tracking. This study determines the geometric accuracy of the tracking.
MATERIALS AND METHODS: To determine the tracking error, an 1D moving phantom produced sinusoidal motion with frequencies up to 30 breaths per minute (bpm). Tumor trajectories of patients were reproduced ...
MATERIALS AND METHODS: To determine the tracking error, an 1D moving phantom produced sinusoidal motion with frequencies up to 30 breaths per minute (bpm). Tumor trajectories of patients were reproduced ...
A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking Universiteit Antwerpen Vrije Universiteit Brussel
Purpose: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. Methods and materials: Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion ...
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy Vrije Universiteit Brussel
Physicians considering stereotactic ablative body radiation therapy (SBRT) for the treatment of extracranial cancer targets must be aware of the sizeable risks for normal tissue injury and the hazards of physical tumor miss. A first-of-its-kind SBRT platform achieves high-precision ablative radiation treatment through a combination of versatile real-time imaging solutions and sophisticated tumor tracking capabilities. It uses dual-diagnostic ...