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Association of depression and epilepsy in Rwanda : a prospective longitudinal study Universiteit Gent

Fidele Sebera, Peter Dedeken, Ieme Garrez, Josiane Umwiringirwa, Tim Leers, Jean-Pierre Ndacyayisenga, Sylvestre Mutungirehe, Arlene Ndayisenga, Odette Niyonzima, Georgette Umuhoza, et al.
Introduction: Depression is the most common psychiatric comorbidity for persons living with epilepsy. In Rwanda, the prevalence of epilepsy and depression are high, with 4,9% and 13.0% respectively. This prospective interventional study aimed to determine the prevalence and incidence of depression and the outcome of persons living with epilepsy (PwE) with depression attending the outpatient neurology department of a tertiary center. Methods: ...

Menopause could be involved in the pathogenesis of muscle and joint aches in mid-aged women KU Leuven

Peter Chedraui
BACKGROUND: Muscle and joint aches (MJA) are frequently observed among menopausal women. They impair quality of life and are a burden to the healthcare system. OBJECTIVE: To analyze the relation between MJA and several variables related to the menopause. METHODS: In this cross-sectional study, 8373 healthy women aged 40-59 years, accompanying patients to healthcare centers in 18 cities of 12 Latin American countries, were asked to fill out the ...

Assessment of subjective sleep disturbance and related factors during female mid-life with the Jenkins Sleep Scale KU Leuven

Peter Chedraui
OBJECTIVE: To assess sleep disturbance and related factors among mid-aged women. METHODS: This was a cross-sectional study in which 288 women (40-59 years) were requested to complete the Jenkins Sleep Scale (JSS), the 12-item General Health Questionnaire (GHQ-12), the Menopause Rating Scale (MRS) and a general socio-demographic questionnaire containing female and partner data. RESULTS: Median [interquartile range] age of the whole sample was 47 ...

Patient characteristics predicting better treatment outcomes in day hospitals compared with inpatient wards KU Leuven

Ulrich Reininghaus
The study aimed to identify patient characteristics associated with differences in outcomes of acute treatment in day hospitals and conventional hospital wards. Methods: Data were from the European Day Hospital Evaluation (EDEN) (2000-2003), a multicenter randomized controlled trial comparing acute treatment in day hospitals and conventional wards in five European countries. All 880 adult patients in the EDEN study who had a diagnosis of ...

Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment? Vrije Universiteit Brussel Universiteit Gent Universiteit Antwerpen

Hans Debruyne, Michael Van Buggenhout, Nathalie Le Bastard, Kurt Audenaert, Peter Paul De Deyn, Sebastiaan Engelborghs

OBJECTIVE: To determine the reliability of the 30-item Geriatric Depression Scale (GDS-30) for the screening of depressive symptoms in dementia and mild cognitive impairment (MCI) using the Cornell Scale for Depression in Dementia (CSDD) as the 'gold standard'.

METHODS: Diagnosed according to strictly applied clinical diagnostic criteria, patients with MCI (n = 156) and probable Alzheimer's disease (AD) (n = 247) were included. ...

Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions Vrije Universiteit Brussel Universiteit Antwerpen

Doortje W Dekens, Sebastiaan Engelborghs, Yannick Vermeiren, Debby Van Dam, Richard C Oude Voshaar, Peter De Deyn

Co-existing depression worsens Alzheimer's disease (AD) pathology. Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression. This study aimed to compare NGAL levels in healthy controls, AD without depression (AD-D), and AD with co-existing depression (AD+D) patients. Protein levels of NGAL and its receptors, 24p3R and megalin, were assessed in nine ...

Diagnostic Impact of Cerebrospinal Fluid Biomarker (Pre-)Analytical Variability in Alzheimer's Disease Vrije Universiteit Brussel Universiteit Antwerpen

Ellis Niemantsverdriet, Joery Goossens, Hanne Struyfs, Jean-Jacques Martin, Johan Goeman, Peter Paul De Deyn, Hugo Vanderstichele, Sebastiaan Engelborghs

Intra- and inter-laboratory variability of cerebrospinal fluid (CSF) biomarker analyses remains an important issue. We investigated the clinical-diagnostic impact of CSF biomarker concentration shifts in mild cognitive impairment (MCI) and autopsy-confirmed Alzheimer's disease (AD) dementia patients. MCI patients (n = 85), autopsy-confirmed AD dementia patients (n = 72), and cognitively healthy controls (n = 100) were included in this ...

Elevated concentrations of neurofilament light chain in the cerebrospinal fluid of bipolar disorder patients Vrije Universiteit Brussel Universiteit Antwerpen

Joel Jakobsson, Maria Bjerke, Carl Johan Ekman, Carl Sellgren, Anette G M Johansson, Henrik Zetterberg, Kaj Blennow, Mikael Landén

Bipolar disorder (BD) is characterized by mood swings between manic and depressive states. The etiology and pathogenesis of BD is unclear, but many of the affected cognitive domains, as well as neuroanatomical abnormalities, resemble symptoms and signs of small vessel disease. In small vessel disease, cerebrospinal fluid (CSF) markers reflecting damages in different cell types and subcellular structures of the brain have been established. ...

Cognitive decline in an old woman Vrije Universiteit Brussel

Nathalie Compte, Sandra De Breucker, Guy Decaux, Jean-Christophe Bier, Thierry Pepersack

Delirium is common in older people. It is a crucial diagnosis because it raises the morbidity and the mortality. Diagnostic tools like Mini Mental State Examination (MMSE), the confusion assessment method (CAM), and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSMIV), can help with the diagnosis. We report a case of a woman with neurological symptoms which look like dementia. We diagnosed systemic lupus ...

Less cognitive and neurological deficits in schizophrenia patients carrying risk variant in ZNF804A Vrije Universiteit Brussel Universiteit Antwerpen

Maarten J A Van Den Bossche, Lise Docx, Manuel Morrens, Sophia Cammaerts, Mojca Strazisar, Chris Bervoets, Stefanie Smolders, Veerle Depreeuw, An-Sofie Lenaerts, Peter De Rijk, et al.

BACKGROUND: The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for a subtype of schizophrenia with relatively spared cognition.

METHODS: We tested the effect of rs1344706 genotype in ...