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Using longitudinal data from a clinical trial in depression to assess the reliability of its outcome scales Universiteit Hasselt KU Leuven

Annouschka LAENEN, Ariel ALONSO ABAD, Geert MOLENBERGHS, Craig H. Mallinckrodt, Tony VANGENEUGDEN
Longitudinal studies are permeating clinical trials in psychiatry. Additionally, in the same field, rating scales are frequently used to evaluate the status of the patients and the efficacy of new therapeutic procedures. Therefore, it is of utmost importance to study the psychometric properties of these instruments within a longitudinal framework. In the area of depression, the Hamilton depression rating scale (HAMD) is regularly used for ...

Psychobehavioral predictors of somatoform disorders in patients with suspected allergies Vrije Universiteit Brussel

Constanze Hausteiner-Wiehle, Susanne Bornschein, Esther Bubel, Sylvie Groben, Claas Lahmann, Martine Grosber, Bernd Löwe, Florian Eyer, Bernadette Eberlein, Heidrun Behrendt, et al.

OBJECTIVE: To explore a combination of health-related psychobehavioral features as potential positive criteria for somatoform disorders (SFD). Currently, SFD can only be diagnosed in the absence of sufficient organic symptom explanation, resulting in low criterion validity and delay of appropriate therapy.

METHODS: Cross sectionally, we studied various psychobehavioral characteristics of 197 inpatients with suspected allergies. At the ...

Epidemiology of major depression in Belgian parkinsonian patients Vrije Universiteit Brussel

Jean-Emile Vanderheyden, Michel Gonce, Philip Bourgeois, Patrick Cras, André Roch De Nayer, Anja Flamez, Frédéric Supiot, Anne-Françoise Donneau, Adelin Albert, Valérie Berlaimont, et al.

BACKGROUND: Epidemiological data concerning the prevalence of major depression in PD patients in Belgium is very scarce.

METHODS: A total of 1086 patients with idiopathic Parkinsons disease were included in the analysis. The neurological evaluation of the patients was made by the Hoehn and Yahr Staging of Parkinsons disease, the Unified Parkinson Disease Rating Scale (UPDRS), and the Schwab and England Activities of Daily Living. The ...

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression. Vrije Universiteit Brussel Universiteit Gent

Chris Baeken, Rudi De Raedt, Liesbeth Santermans, Dieter Zeeuws, Marie-Anne Vanderhasselt, M. Meers, Nathalie Vanderbruggen
Repetitive Transcranial Magnetic Stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising treatment strategy for depression. As one of the key features of melancholic depression is disturbances in psychomotor activity, we wanted to evaluate whether HF-rTMS treatment could influence psychomotor symptoms. Twenty antidepressant-free unipolar melancholic depressed patients, all at least stage III ...

Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease Vrije Universiteit Brussel Universiteit Antwerpen

Stefan Van der Mussele, Kim Bekelaar, Nathalie Le Bastard, Yannick Vermeiren, Jos Saerens, Nore Somers, Peter Mariën, Johan Goeman, Peter De Deyn, Sebastiaan Engelborghs, et al.

BACKGROUND: Mild cognitive impairment (MCI) is a clinical concept that categorizes subjects who are in an intermediate cognitive state between normal aging and dementia. The aims of this study are to determine the prevalence of significant depressive symptoms in MCI and Alzheimer's disease (AD) patients and to characterize the behavior associated with significant depressive symptoms in MCI and AD patients.

METHODS: A cross-sectional ...

Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence Vrije Universiteit Brussel Universiteit Antwerpen

Cleo L Crunelle, Wim van den Brink, Dick J. Veltman, Katelijne van Emmerik-van Oortmerssen, Geert Dom, Robert A Schoevers, Jan Booij

Methylphenidate (MPH) occupies brain striatal dopamine transporters (DATs) and is an effective treatment for attention deficit hyperactivity disorder (ADHD). However, patients with ADHD and comorbid cocaine dependence do not benefit significantly from treatment with MPH. To better understand the neurobiology of this phenomenon, we examined DAT availability and the effects of MPH treatment on DAT occupancy in ADHD patients with and without ...

De relatie tussen apathie, depressie en cognitief functioneren bij patiënten met MCI en dementie Vrije Universiteit Brussel Universiteit Antwerpen

Robin Vloeberghs, Esther M Opmeer, Peter De Deyn, Sebastiaan Engelborghs, Ellen De Roeck

BACKGROUND: In dementia, apathy and depression are often seen as one disorder because of the many overlapping symptoms. However, for therapy a correct differentiation is essential. Moreover, apathy and depression are likely both associated with different cognitive deficits and progression of the disease. In this research we give an overview of cognitive domains associated with apathy and depression in MCI patients and report how often both ...

Prevalence and clinical characteristics of remission during treatment in generalized anxiety Vrije Universiteit Brussel Universiteit Antwerpen

Marianne Destoop, Filip Van Den Eede, Marc Ansseau, Adelin Albert, Sophie Vanbelle, Annick Mignon, Patricia Slachmuylders, Bernard Sabbe

OBJECTIVE: Although the remission criteria for generalized anxiety are well defined, there is not much data available on the point prevalence of remission. The Measuring Impact of Remission in Anxiety Disorders in Belgium (MIRABEL) study is a naturalistic study designed to document the point prevalence of remission in patients treated for general anxiety and potential factors affecting this prevalence.

METHODS: The study population ...

The longitudinal course of cognitive insight and mood in bipolar disorder Vrije Universiteit Brussel Universiteit Antwerpen

Lynn Van Camp, Seline van den Ameele, Bernard Sabbe, J F E Oldenburg

Cognitive insight or the ability to be self-reflective and to retain from being over-confident in own beliefs is an upcoming topic in research regarding psychiatric disorders. In bipolar disorder investigations are scarce and an important lacuna is the unexamined longitudinal relationship between cognitive insight and mood. Therefore, in this study the level of cognitive insight, mania and depression were assessed in a total of 56 patients ...

EEG connectivity between the subgenual anterior cingulate and prefrontal cortices in response to antidepressant medication Vrije Universiteit Brussel Universiteit Gent

Tabitha A Iseger, Mayuresh S Korgaonkar, J Leon Kenemans, Stuart M Grieve, Chris Baeken, Martijn Arns

Antidepressant medication is the most common treatment for major depressive disorder (MDD), however, the precise working mechanism underlying these treatments remains unclear. Recent neuromodulation treatments demonstrate that direct stimulation of the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and subgenual anterior cingulate (sgACC) relate to clinical improvement, suggesting connectivity alterations of ...