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Siderophore-mediated iron acquisition in the entomopathogenic bacterium Pseudomonas entomophila L48 and Pseudomonas putida KT2440 Vrije Universiteit Brussel
Pseudomonas entomophila L48 is a recently identified entomopathogenic bacterium which, upon ingestion, kills Drosophila melanogaster, and is closely related to P. putida. The complete genome of this species has been sequenced and therefore a genomic, genetic and structural analysis of the siderophore-mediated iron acquisition was undertaken. P. entomophila produces two siderophores, a structurally new and unique pyoverdine and the secondary ...
Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections. Vrije Universiteit Brussel
Pseudomonas aeruginosa is a Gram-negative ?-Proteobacterium which is known for its capacity to colonize various niches, including some invertebrate and vertebrate hosts, making it one of the most frequent bacteria causing opportunistic infections. P. aeruginosa is able to cause acute as well as chronic infections and it uses different colonization and virulence factors to do so. Infections range from septicemia, urinary infections, burn wound ...
Analysis of the draft genome of Pseudomonas fluorescens ATCC17400 indicates a capacity to take up iron from a wide range of sources, including different exogenous pyoverdines Vrije Universiteit Brussel
All fluorescent pseudomonads (Pseudomonas aeruginosa, P. putida, P. fluorescens, P. syringae and others) are known to produce the high-affinity peptidic yellow-green fluorescent siderophore pyoverdine. These siderophores have peptide chains that are quite diverse and more than 50 pyoverdine structures have been elucidated. In the majority of the cases, a Pseudomonas species is also able to produce a second siderophore of lower affinity for iron. ...
A proteome analysis of the response of a Pseudomonas aeruginosa oxyR mutant to iron limitation Universiteit Hasselt
In Pseudomonas aeruginosa the response to oxidative stress is orchestrated by the LysR regulator OxyR by activation of the transcription of two catalase genes (katA and katB), of the alkyl-hydroxyperoxidases ahpCF and ahpB. Next to the expected high sensitivity to oxidative stress generated by reactive oxygen species (ROS: H2O2, O-2 (-)), the oxyR mutant shows a defective growth under conditions of iron limitation (Vinckx et al. 2008). Although ...
Loss of the oxidative stress regulator OxyR in Pseudomonas aeruginosa PAO1 impairs growth under iron limited conditions Vrije Universiteit Brussel
Pyoverdine is the main siderophore secreted by fluorescent pseudomonads to
scavenge iron in the extracellular environment. Iron uptake, however, needs to be
tightly regulated, because free iron stimulates the formation of highly toxic oxygen
derivatives. In the opportunistic pathogen Pseudomonas aeruginosa, the transcriptional
regulator OxyR plays a key role in the upregulation of defense mechanisms
against ...
scavenge iron in the extracellular environment. Iron uptake, however, needs to be
tightly regulated, because free iron stimulates the formation of highly toxic oxygen
derivatives. In the opportunistic pathogen Pseudomonas aeruginosa, the transcriptional
regulator OxyR plays a key role in the upregulation of defense mechanisms
against ...
Iron uptake regulation in Pseudomonas aeruginosa Vrije Universiteit Brussel
The Pseudomonas genus belongs to the gamma division of Proteobacteria and many species produce the characteristic yellow-green siderophore pyoverdine, and often a second siderophore, of lower affinity for iron. These bacteria are known for their ability to colonize different ecological niches and for their versatile metabolism. It is therefore not surprising that they are endowed with the capacity to take up exogenous xenosiderophores via ...
A proteome analysis of the response of a Pseudomonas aeruginosa oxyR mutant to iron limitation. Vrije Universiteit Brussel
In Pseudomonas aeruginosa the response to oxidative stress is orchestrated by the LysR regulator OxyR by activation of the transcription of two catalase genes (katA and katB), of the alkyl-hydroxyperoxidases ahpCF and ahpB. Next to the expected high sensitivity to oxidative stress generated by reactive oxygen species (ROS: H(2)O(2), O(2) (-)), the oxyR mutant shows a defective growth under conditions of iron limitation (Vinckx et al. 2008). ...
High affinity iron uptake by pyoverdine in Pseudomonas aeruginosa involves multiple regulators besides Fur, PvdS, and FpvI Vrije Universiteit Brussel
Pseudomonas aeruginosa is a Gram-negative bacterium which can cause serious infections among immune-depressed people including cystic fibrosis patients where it can colonize the lungs causing chronic infections. Iron is essential for P. aeruginosa and can be provided via three sources under aerobic conditions: its own siderophores pyochelin (PCH) and pyoverdine (PVD), xenosiderophores, or heme, respectively. Pyoverdine is the high affinity ...
Iron uptake regulation in Pseudomonas aeruginosa KU Leuven
The Pseudomonas genus belongs to the γ division of Proteobacteria and many species produce the characteristic yellow–green siderophore pyoverdine, and often a second siderophore, of lower affinity for iron. These bacteria are known for their ability to colonize different ecological niches and for their versatile metabolism. It is therefore not surprising that they are endowed with the capacity to take up exogenous xenosiderophores via different ...