Publicaties

BACKGROUND AND OBJECTIVES: Behavioral and neuropsychiatric symptoms are frequent in patients with genetic frontotemporal dementia (FTD). We aimed to describe behavioral and neuropsychiatric phenotypes in genetic FTD, quantify their temporal association, and investigate their regional association with brain atrophy. METHODS: We analyzed data of pathogenic variant carriers in the chromosome 9 open reading frame 72 (c9orf72), progranulin (GRN), or ...

This study presents a biphasic approach to overcome the limitations of current testicular organoid (TO) cultures, including histological heterogeneity, germ cell loss and absence of spermatogenesis. Agarose microwells were utilized to create TOs from prepubertal C57BL/6 J testicular cells. First emphasis was on improving germ cell survival during the initial 2-week reorganization phase by comparing α-MEM + 10% knockout serum replacement (KSR) ...

Pests and plant pathogens threaten global food availability. Currently, farmers heavily rely on chemical pesticides to combat these threats, but their extensive use has led to some unintended consequences, such as the emergence of resistant pathogens. Moreover, concerns have been raised about their impact on the environment and human health. Integrated pest management (IPM), a strategy that prioritizes the use of sustainable methods, is one of ...

Alzheimer's disease is one of the causes associated with the early stages of dementia. Nowadays, the main treatment available is to inhibit the actions of the acetylcholinesterase (AChE) enzyme, which has been identified as responsible for the disease. In this study, computational methods were used to examine the structure and therapeutic ability of chemical compounds extracted from Millettia brandisiana natural products against AChE. This plant ...

Many people underestimate the impact ageing can have on their life. Most often those persons only have some of the typical macroscopic characteristics of ageing, such as wrinkles, grey hair, a slower reaction time, and minor functional loss of their sight and/or hearing. Those are, however, the few lucky ones. Indeed, within the greying society, an increasing number of seniors are succumbing to age-related diseases. Many organs are at risk to ...

Plant uptake, accumulation, and transformation of organophosphate esters (OPEs) play vital roles in their geochemical cycles and exposure risks. Here we reviewed the recent research advances in OPEs in plants. The mean OPE concentrations based on dry/wet/lipid weight varied in 4.80–3,620/0.287–26.8/12,000–315,000 ng g−1 in field plants, and generally showed positive correlations with those in plant habitats. OPEs with short-chain substituents ...

CONTEXT: Genetic variation in sex hormone-binding globulin (SHBG) structure may affect estimates of sex steroid exposure by altering the affinity of the protein for its ligand. Consequently, free hormone calculations assuming constant binding affinity may, for certain genetic variations, lead to incorrect diagnoses if genetic variation is not taken into consideration. OBJECTIVE: To investigate the effects of genetic variation in SHBG on ...

Decellularized matrices are an attractive choice of scaffold in regenerative medicine as they can provide the necessary extracellular matrix (ECM) components, signals and mechanical properties. Various detergent-based protocols have already been proposed for decellularization of skeletal muscle tissue. However, a proper comparison is difficult due to differences in species, muscle origin and sample sizes. Moreover, a thorough evaluation of the ...

Neuraminidases (NA) are sialic acid-cleaving enzymes that are used by both bacteria and viruses. These enzymes have sialoside structure-related binding and cleaving preferences. Differentiating between these enzymes requires using a large array of hard-to-access sialosides. In this work, we used electrochemical impedimetric biosensing to differentiate among several pathogene-related NAs. We used a limited set of sialosides and tailored the ...

Bone grafts are commonly used in orthopedics, traumatology, and oral and maxillofacial surgery for treating bone defects caused by trauma, oncologic resection, congenital malformations, and prosthetic treatments. There are still limitations and complications associated with the current standard of using autologous bone tissue as grafts. These include donor site morbidity, inadequate quantities of available donor tissue, ultimate poor tissue ...