Publicaties

Potato proteins have been shown to be suitable alternatives for animal proteins in food foam formulations but their ability to form and stabilize foam is mechanistically ill-understood. The present study aimed to better understand the foaming properties of a protein fraction isolated from potato trimmings, a by-product from the potato industry. This was achieved by comparing the properties of these in-house isolated proteins to those of ...

Maize zein based nanoparticles (ZNPs) can have applications as food dispersion stabilizers. It has not been documented to what extent the used zein isolation method and conditions thereof impact the structure and functionality of nanoparticles (NPs) based thereupon. Here, zein extracted from maize flour on lab scale (LS-zein) was compared with a commercial zein powder (CS-zein). On a dry matter basis, CS-zein contained 96.5% protein, while ...

BACKGROUND AND OBJECTIVES: Behavioral and neuropsychiatric symptoms are frequent in patients with genetic frontotemporal dementia (FTD). We aimed to describe behavioral and neuropsychiatric phenotypes in genetic FTD, quantify their temporal association, and investigate their regional association with brain atrophy. METHODS: We analyzed data of pathogenic variant carriers in the chromosome 9 open reading frame 72 (c9orf72), progranulin (GRN), or ...

This study presents a biphasic approach to overcome the limitations of current testicular organoid (TO) cultures, including histological heterogeneity, germ cell loss and absence of spermatogenesis. Agarose microwells were utilized to create TOs from prepubertal C57BL/6 J testicular cells. First emphasis was on improving germ cell survival during the initial 2-week reorganization phase by comparing α-MEM + 10% knockout serum replacement (KSR) ...

Renal proximal tubular reabsorption of proteins and polypeptides is tightly regulated by a concerted action of the multi-ligand receptors with subsequent processing from the clathrin-coated pits to early/recycling and late endosomes and towards lysosomes. We performed whole exome-sequencing in a male patient from a consanguineous family, who presented with low- and intermediate molecular weight proteinuria, nephrocalcinosis and oligospermia. We ...

Abnormal protein deposition and brain trauma can both lead to hyperphosphorylation and accumulation of tau protein in the brain. In this project, it is hypothesized that sequentially measuring tau protein in combination with the effect on synaptic density, determines further changes such as anatomic and cognitive changes. Both tau deposition and synaptic density can be determined using PET scans (18F-MK6240 en 11C-UCB-J, respectively). Also, ...

Protein aggregation is a common pathological hallmark of a large number of neurodegenerative diseases, such as Alzheimer's and Parkinson's, as well as many metabolic diseases and cancer. This phenomenon results from the self-assembly of short regions of mainly hydrophobic amino acids (APRs) into stacked structured sheets called steric zippers. Mounting evidence suggest that protein post-translational modifications (PTMs) can often increase or ...