Protein phosphatase 2A PR130/B ''alpha 1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling Universiteit Antwerpen KU Leuven
To elucidate novel cell biological functions of specific protein phosphatase 2A (PP2A) holoenzymes, we identified and biochemically characterized a complex between the Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2) and a PP2A holoenzyme comprising PR130/B ''alpha 1 as a regulatory subunit (PP2A(T130)) in several mammalian cell lines. PR130/B ''alpha 1 and SHIP2 partially colocalize in untreated HeLa cells, ...