Corynebacterium diphtheriae methionine sulfoxide reductase A exploits a unique mycothiol redox relay mechanism Vrije Universiteit Brussel
Methionine sulfoxide reductases are conserved enzymes that reduce oxidized methionines in proteins, and play a pivotal role in cellular redox signaling. We have unraveled the redox relay mechanisms of methionine sulfoxide reductase A of the pathogen C. diphtheria (Cd-MsrA), and showed that this enzyme is coupled to two independent redox relay pathways. Steady-state kinetics combined with mass spectrometry of Cd-MsrA mutants give a view of the ...