Publicaties
PubMed-scale event extraction for post-translational modifications, epigenetics and protein structural relations Universiteit Gent
In vivo regulation of chemokine activity by post-translational modification Vrije Universiteit Brussel KU Leuven
Cytokines and chemokines represent two important groups of proteins that control the immune system. Dysregulation of the network in which these immunomodulators function can result in uncontrolled inflammation leading to various diseases, including rheumatoid arthritis, characterized by chronic inflammation and bone erosion. Chemokine activity is regulated at multiple levels, such as post-translational modification (PTM) of chemokines and ...
Regulation of connexin- and pannexin-based channels by post-translational modifications KU Leuven Universiteit Gent
Regulation of connexin- and pannexin-based channels by post-translational modifications Vrije Universiteit Brussel
function as regulators of communication between neighboring cells via gap junctions
and/or hemichannels. Intercellular communication is essential to coordinate cellular
responses in tissues and organs, thereby fulfilling an essential role in the spreading of
signaling, survival and death processes. The functional properties of gap junctions ...
The role of the post-translational modification citrullination in type 1 diabetes KU Leuven
Interaction between the beta-cell and the immune system in type 1 diabetes: role for post-translational modifications KU Leuven
Effect of posttranslational processing on the in vitro and in vivo activity of chemokines Vrije Universiteit Brussel KU Leuven
The CXC and CC chemokine gene clusters provide an abundant number of chemotactic factors selectively binding to shared G protein-coupled receptors (GPCR). Hence, chemokines function in a complex network to mediate migration of the various leukocyte subsets, expressing specific GPCRs during the immune response. Further fine-tuning of the chemokine system is reached through specific posttranslational modifications of the mature proteins. ...
Protein S-mycothiolation functions as redox-switch and thiol protection mechanism in Corynebacterium glutamicum under hypochlorite stress Vrije Universiteit Brussel
AIMS: Protein S-bacillithiolation was recently discovered as important thiol protection and redox-switch mechanism in response to hypochlorite stress in Firmicutes bacteria. Here we used transcriptomics to analyze the NaOCl stress response in the mycothiol (MSH)-producing Corynebacterium glutamicum. We further applied thiol-redox proteomics and mass spectrometry (MS) to identify protein S-mycothiolation.
RESULTS: Transcriptomics ...
Protein carbamylation and cardiovascular disease Vrije Universiteit Brussel
Carbamylation constitutes a posttranslational modification of proteins or amino acids and results from different pathways in vivo. First is the non-enzymatic reaction between isocyanic acid, a decomposition product of urea, and either the N-terminus or the ɛ-amino group of lysine residues. Isocyanic acid levels, while low in vivo, are in equilibrium with urea and are thus increased in chronic and end-stage renal diseases. An alternative ...