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Evaluation of a generic in vivo approach for the site-specific modification of proteins with a 'click chemistry functionalized amino acid' for the development of innovative bioactive materials Universiteit Hasselt
The site-specific modification of proteins is of great importance for the development and improvement of many biotechnological applications (e.g. biosensors). The focus of this work is the in vivo site-specific modification of proteins by means of amber suppression. As a result, a non-natural amino acid can be introduced to the protein, which can serve as a unique chemical “handle” to immobilize proteins in an oriented and covalent way, ...
Polycrystalline Diamond Coating on Orthopedic Implants: Realization and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation Interuniversitair Micro-Electronica Centrum vzw
Polycrystalline diamond has the potential to improve the osseointegration of orthopedic implants compared to conventional materials such as titanium. However, despite the excellent biocompatibility and superior mechanical properties, the major challenge of using diamond for implants, such as those used for hip arthroplasty, is the limitation of microwave plasma chemical vapor deposition (CVD) techniques to synthesize diamond on complex-shaped ...
The expanding role of chemistry in optimizing proteins for human health applications Universiteit Gent
Patchwork protein chemistry: a practitioner's treatise on the advances in synthetic peptide stitchery Universiteit Gent
Interactions between oxidizing lipids and proteins: a complex and understudied research area in food chemistry Universiteit Gent
The Mechanism of Biochemical NO-Sensing: Insights from Computational Chemistry KU Leuven
The binding of small gas molecules such as NO and CO plays a major role in the signaling routes of the human body. The sole NO-receptor in humans is soluble guanylyl cyclase (sGC) - a histidine-ligated heme protein, which, upon NO binding, activates a downstream signaling cascade. Impairment of NO-signaling is linked, among others, to cardiovascular and inflammatory diseases. In the present work, we use a combination of theoretical tools such as ...
Chemistry Between Salamanders: Evolution of the SPF Courtship Pheromone System in Salamandridae Vrije Universiteit Brussel
Chemical communication is an important aspect of courtship and reproduction in salamanders (Urodela), where males secrete several protein pheromones from various sexually dimorphic glands. The most widely used sex pheromone system consists of proteins of the Sodefrin Precursor-like Factor (SPF) family. This protein family already started diversifying through gene duplications in the Late Palaeozoic and continued to do so in various urodelan ...