Publicaties
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Blood-based biomarkers for precision medicine in lung cancer: precision radiation therapy KU Leuven
Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must take into account this variability as well as its dynamic state. The genetic features of the tumor and the host, and increasingly also the epi-genetic and proteomic characteristics, are being unraveled. Multiple techniques, including histological examination, blood sampling, measurement of circulating tumor ...
Evaluation of precision medicine assessment reports of the Belgian healthcare payer to inform reimbursement decisions Vlerick Business School KU Leuven
Introduction.Precision medicines rely on companion diagnostics to identify patient subgroups eligible for receiving the pharmaceutical product. Until recently, the Belgian public health payer, RIZIV-INAMI, assessed precision medicines and companion diagnostics separately for reimbursement decisions. As both components are considered co-dependent technologies, their assessment should be conducted jointly from a health technology assessment (HTA) ...
Precision medicine and drug development in Alzheimer's disease : the importance of sexual dimorphism and patient stratification Universiteit Gent
The treatment of multiple myeloma in an era of precision medicine Universiteit Gent KU Leuven
Integrating Rehabilomics into the Multi-Omics Approach in the Management of Multiple Sclerosis: The Way for Precision Medicine? Universiteit Hasselt
Over recent years, significant improvements have been made in the understanding of (epi)genetics and neuropathophysiological mechanisms driving the different forms of multiple sclerosis (MS). For example, the role and importance of the bidirectional communications between the brain and the gut—also referred to as the gut-brain axis—in the pathogenesis of MS is receiving increasing interest in recent years and is probably one of the most ...
A roadmap towards precision medicine in asthma Universiteit Gent
Combined longitudinal clinical and autopsy phenomic assessment in lethal metastatic prostate cancer : recommendations for advancing precision medicine Universiteit Gent
Advancing pediatric precision healthcare : integrating rapid metabotyping as a fundamental component for 4P medicine Universiteit Gent
Introduction: The rising incidence of pediatric obesity and associated comorbidities prompts the search for effective therapeutic approaches. To address this problem, we propose 2D conventional and ambient ionization-based metabolomics and lipidomics, which possess tremendous potential in the context of weight stratification (metabotyping) and provides researchers with unparalleled insights into the complex metabolic processes of the human body. ...
Advancing pediatric precision healthcare : integrating rapid metabotyping as a fundamental component for 4P medicine through source-driven metabolome predictions Universiteit Gent
Background: The rising incidence of pediatric obesity and associated comorbidities has created an urgent need for effective therapeutic approaches. To address this problem, I propose metabolomics, which possesses tremendous potential to elucidate metabotypes (e.g., metabolomic fingerprinting based on weight stratification) and provide researchers with unparalleled insights into the complex metabolic processes of the human body. Material and ...