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7-Aryl-7-deazapurine 3 '-deoxyribonucleoside derivative as a novel lead for Chagas' disease therapy : in vitro and in vivo pharmacology Universiteit Gent Universiteit Antwerpen
Background The protozoan Trypanosoma cruzi is auxotrophic for purines and causes Chagas' disease (CD), a neglected illness affecting >6 million people. Combining the 3-deoxyribofuranose part of cordycepin with the modified purine ring of a nucleoside 'hit' led to the discovery of 4-amino-5-(4-chlorophenyl)-N7-(3 '-deoxy-beta-d-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine (Cpd1), revealing promising anti-T. cruzi activity. Objectives To further ...
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies Universiteit Antwerpen
Introduction: A safety pharmacology study detects and evaluates potential side effects of a new drug on physiological function at therapeutic levels and above and, in most cases, prior to the initiation of clinical trials. The aim of this study was to investigate the effects of environmental and biological factors on resting heart rate (HR), a representative cardiac parameter in cardiovascular safety pharmacology. Methods: Over twenty years, 143 ...
Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19 Universiteit Antwerpen Universiteit Gent Instituut voor Tropische Geneeskunde
Purpose Nasal irrigation or nebulizing aerosol of isotonic or hypertonic saline is a traditional method for respiratory or nasal care. A recent small study in outpatients with COVID-19 without acute respiratory distress syndrome suggests substantial symptom resolution. We therefore analyzed pharmacological/pharmacodynamic effects of isotonic or hypertonic saline, relevant to SARS-CoV-2 infection and respiratory care. Methods Mixed search method. ...
Clinical pharmacology of exogenously administered alkaline phosphatase Universiteit Antwerpen
Purpose To evaluate the clinical pharmacology of exogenous alkaline phosphatase (AP). Methods Randomized, double-blind, placebo-controlled sequential protocols of (1) ascending doses and infusion duration (volunteers) and (2) fixed dose and duration (patients) were conducted at clinical pharmacology and intensive care units. A total of 103 subjects (67 male volunteers and 36 patients with severe sepsis) were administered exogenous, 10-min IV ...
Pharmacology of novel drugs against visceral leishmaniasis and African trypanosomiasis Universiteit Antwerpen
Visceral leishmaniasis (VL) and human African trypanosomiasis (HAT) are tropical neglected diseases caused by the respective parasites, Leishmania infantum or L. dononani and Trypanosoma brucei gambiense or T. b. rhodesiense. These parasite species can cause serious infections resulting in serious clinical symptoms and eventual death when left untreated. Current treatment options for VL and HAT are less than adequate as they lack efficacy, are ...
A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force Vrije Universiteit Brussel
Preclinical pharmacology studies in animal models of seizures and epilepsy have provided a platform to identify more than 20 antiseizure drugs in recent decades. To minimize variability in lab-to-lab studies and to harmonize approaches to data collection and reporting methodology in pharmacologic evaluations of the next generation of therapies, we present common data elements (CDEs), case report forms (CRFs), and this companion manuscript to ...