Paving a regulatory pathway for phage therapy - Europe should muster the resources to financially, technically and legally support the introduction of phage therapy Vrije Universiteit Brussel
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Paving a regulatory pathway for phage therapy. Europe should muster the resources to financially, technically and legally support the introduction of phage therapy KU Leuven
The growing problem of antibiotic-resistant bacteria has re-kindled interest in phage-based therapies. Yet, the use of phages to treat life-threatening bacterial infections is held back by the lack of an appropriate regulatory framework for phage therapy.
Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains KU Leuven
Phage therapy is increasingly put forward as a "new" potential tool in the fight against antibiotic resistant infections. During the "Centennial Celebration of Bacteriophage Research" conference in Tbilisi, Georgia on 26-29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper ...
Romulus and Remus, Two Phage Isolates Representing a Distinct Clade within theTwortlikevirus Genus, Display Suitable Properties for Phage Therapy Applications. Universiteit Hasselt KU Leuven Universiteit Gent
The renewed interest in controlling Staphylococcus aureus infections using their natural enemies, bacteriophages, has led to the isolation of a limited number of virulent phages so far. These phages are all members of the Twortlikevirus, displaying little variance. We present two novel closely related (95.9% DNA homology) lytic myoviruses, Romulus and Remus, with double-stranded DNA (dsDNA) genomes of 131,333 bp and 134,643 bp, respectively. ...
Current challenges and future opportunities of phage therapy Universiteit Gent
Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last ...
Processing phage therapy requests in a Brussels Military Hospital: lessons identified Instituut voor Tropische Geneeskunde
There is a growing interest in phage therapy as a complementary tool against antimicrobial resistant infections. Since 2007, phages have been used sporadically to treat bacterial infections in well-defined cases in the Queen Astrid military hospital (QAMH) in Brussels, Belgium. In the last two years, external requests for phage therapy have increased significantly. From April 2013 to April 2018, 260 phage therapy requests were addressed to ...
Experimental phage therapy of burn wound infection UZBrussel
Antibiotic resistance has become a major public health problem and the antibiotics pipeline is running dry. Bacteriophages (phages) may offer an 'innovative' means of infection treatment, which can be combined or alternated with antibiotic therapy and may enhance our abilities to treat bacterial infections successfully. Today, in the Queen Astrid Military Hospital, phage therapy is increasingly considered as part of a salvage therapy for ...
In vitro and in vivo assessment of phage therapy against Staphylococcus aureus causing bovine mastitis Instituut voor Landbouw-, Visserij- en Voedingsonderzoek KU Leuven Universiteit Gent
Objective
The aim of this study was to assess the efficacy of lytic bacteriophages on Staphylococcus aureus causing bovine mastitis, by in vitro and in vivo assays using Galleria mellonella and murine mastitis models.
Methods
Between May and December 2016, ten S. aureus (five methicillin-resistant and five methicillin-sensitive) isolates were isolated from milk samples of cattle with mastitis in Belgium and Norway. The ...
The aim of this study was to assess the efficacy of lytic bacteriophages on Staphylococcus aureus causing bovine mastitis, by in vitro and in vivo assays using Galleria mellonella and murine mastitis models.
Methods
Between May and December 2016, ten S. aureus (five methicillin-resistant and five methicillin-sensitive) isolates were isolated from milk samples of cattle with mastitis in Belgium and Norway. The ...
The Phage Therapy Paradigm: Prêt-à -Porter or Sur-mesure? Vrije Universiteit Brussel Universiteit Gent KU Leuven
Quality and safety requirements for sustainable phage therapy products Vrije Universiteit Brussel KU Leuven Universiteit Gent
The worldwide antibiotic crisis has led to a renewed interest in phage therapy. Since time immemorial phages control bacterial populations on Earth. Potent lytic phages against bacterial pathogens can be isolated from the environment or selected from a collection in a matter of days. In addition, phages have the capacity to rapidly overcome bacterial resistances, which will inevitably emerge. To maximally exploit these advantage phages have ...