alpha-Synuclein Abnormalities in Mouse Models of Peroxisome Biogenesis Disorders KU Leuven
alpha-Synuclein (alpha S) is a presynaptic protein implicated in Parkinson's disease (PD). Growing evidence implicates mitochondrial dysfunction, oxidative stress, and alpha S-lipid interactions in the gradual accumulation of alpha S in pathogenic forms and its deposition in Lewy bodies, the pathological hallmark of PD and related synucleinopathies. The peroxisomal biogenesis disorders (PBD), with Zellweger syndrome serving as the prototype of ...