Publicaties
ApoA-I mimetic peptide 5A boosts remyelination by promoting myelin debris clearance Universiteit Hasselt
Downsizing antibodies : towards complementarity-determining region (CDR)-based peptide mimetics Universiteit Gent Vrije Universiteit Brussel
Influence of ring substitution on the conformation and beta-turn mimicry of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one peptide mimetics Vrije Universiteit Brussel
The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris KU Leuven Universiteit Hasselt
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes KU Leuven Universiteit Gent
Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels Universiteit Gent
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation KU Leuven Universiteit Gent
Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence Vrije Universiteit Brussel
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation. This protocol allows the rapid construction of a diverse array of substituted 1,5-benzodiazepinones. Since Ugi-based products are typically limited by their 'inert' C -terminal amides, the use of a convertible ('cleavable') ...
Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. Vrije Universiteit Brussel Universiteit Gent
To address the need for highly potent, metabolically stable, and selective agonists, antagonists, and inverse agonists at the melanocortin receptor subtypes, conformationally constrained indolo- and benzazepinone residues were inserted into the α-MSH pharmacophore, His(6)-Phe(7)-Arg(8)-Trp(9)-domain. Replacement of His(6) by an aminoindoloazepinone (Aia) or aminobenzazepinone (Aba) moiety led to hMC4R and hMC5R selective agonist and ...