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Improving the Golden-headed lion tamarin breeding schemes by establishing founder relatedness through combined microsatellite maker and pedigree analysis Koninklijke Maatschappij voor Dierkunde van Antwerpen Universiteit Hasselt
To conserve a self-sustaining captive population, the population must be genetically managed to minimize loss of genetic diversity, inbreeding and adaptation to captivity. Accurate genetic management of a captive population relies mostly on pedigree analysis. However, the majority of the pedigrees in captive breeding programs are far from perfect for various reasons. Most importantly, founders are assumed to be unrelated, often resulting in an ...
Elucidation of the 'Honeycrisp' pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus x domestica) pedigree-connected SNP data set KU Leuven
The apple (Malus×domestica) cultivar Honeycrisp has become important economically and as a breeding parent. An earlier study with SSR markers indicated the original recorded pedigree of 'Honeycrisp' was incorrect and 'Keepsake' was identified as one putative parent, the other being unknown. The objective of this study was to verify 'Keepsake' as a parent and identify and genetically describe the unknown parent and its grandparents. A ...
Large-scale pedigree analysis highlights rapidly mutating Y-chromosomal short tandem repeats for differentiating patrilineal relatives and predicting their degrees of consanguinity KU Leuven Universiteit Antwerpen
Rapidly mutating Y-chromosomal short tandem repeats (RM Y-STRs) were suggested for differentiating patrilineally related men as relevant in forensic genetics, anthropological genetics, and genetic genealogy. Empirical data are available for closely related males, while differentiation rates for more distant relatives are scarce. Available RM Y-STR mutation rate estimates are typically based on father-son pair data, while pedigree-based studies ...
Sustainable breeding of pedigree dogs KU Leuven
Breeding practices in purebred dogs are highly criticized since the BBC documentary in 2008. Selection for morphological extreme traits has resulted in various anatomical abnormalities and disorders in the pedigree dog population. Furthermore, selection for breed conformity further increased the number of disorders present in these breeds as a result of inbreeding practices and the use of few popular sires. As most dog breeds are closed ...
Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family Vlaams Instituut voor Biotechnologie Universiteit Antwerpen Universiteit Gent KU Leuven Vrije Universiteit Brussel
GENType : all-in-one preimplantation genetic testing by pedigree haplotyping and copy number profiling suitable for third-party reproduction Universiteit Gent Vlaams Instituut voor Biotechnologie
STUDY QUESTION Is it possible to develop a comprehensive pipeline for all-in-one preimplantation genetic testing (PGT), also suitable for parents-only haplotyping and, for the first time, third-party reproduction? SUMMARY ANSWER Optimized reduced representation sequencing (RRS) by GENType, along with a novel analysis platform (Hopla), enables cheap, accurate and comprehensive PGT of blastocysts, even without the inclusion of additional family ...
Whole exome sequencing in a large pedigree with DCM identifies a novel mutation in RBM20 KU Leuven
Background: Familial dilated cardiomyopathy (DCM) is genetically heterogeneous and is associated with mutations in at least 40 different genes. Apart from TTN encoding the giant protein Titin, none of these genes have an expected diagnostic yield of more than 5% complicating genetic diagnosis. Whole exome sequencing (WES) is a powerful alternative for the identification of the causal gene, however variant interpretation remains challenging. We ...
Estimating the penetrance of pathogenic gene variants in families with missing pedigree information Vrije Universiteit Brussel
Accurate assessment of the age-dependent disease risk conferred by germline variants in disease susceptibility genes is often hampered by the way the data are collected. Cohort-based data sets frequently contain an overrepresentation of patients (i.e. carriers of the gene variant of interest affected with the associated disease), and an underrepresentation of disease-free carriers. In order to overcome this problem, penetrance estimates can ...
Semen donation and establishment of an open canine semen bank : a novel tool to prevent inbreeding in pedigree dogs Universiteit Gent
At present, only 5% of pedigree dogs is being used for breeding. To increase the number of breeding dogs, one solution could be to start a canine semen bank based on the principle of semen donation, like in humans. Many dog owners have no desire to become dog breeders but are willing to preserve the genetic material of their dog, if offered this possibility. However, not all canine ejaculates are suitable for cryopreservation as the initial ...