Publicaties

The African Turquoise killifish (Nothobranchius furzeri) is a promising model for age-related research, offering several advantages over traditional, long-lived vertebrate animal models. Its compressed lifespan allows researchers to study the full spectrum of aging, from early life to death, in a short timeframe. In addition to its rapid growth, the killifish exhibits an age-related decline in regenerative capacity and spontaneous neuronal ...

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, clinically characterized by non-motor and motor problems of which freezing of gait (FOG) is one of the most devasting. Dopaminergic medication has an alleviating effect, but gait and balance problems, including FOG, respond only partially to this treatment. FOG usually emerges with increasing disease progression and especially when facing circumstances in ...

Background Microbial melanins possess a broad spectrum of biological activities. However, there is little understanding of their neuroprotective and neuronal cell differentiation properties. This study aimed to extract, purify, and modify melanins from two medicinal fungi (Daedaleopsis tricolor and Fomes fomentarius), and to evaluate their antioxidant activity, as well as their cell protective ability against neurotoxins. In addition, the study ...

BACKGROUND: Tremor in Parkinson's disease (PD) is commonly regarded as less responsive to levodopa than bradykinesia and rigidity, with levodopa-resistant PD tremor considered relatively common. OBJECTIVE: The aim was to assess the levodopa responsiveness of tremor, bradykinesia, and rigidity in a population with advanced PD. METHODS: We performed a retrospective study of 526 people with PD screened for deep brain stimulation. RESULTS: ...

Type 1 diabetes treatment stands at a crucial and exciting crossroad since the 2022 U.S. Food and Drug Administration (FDA) approval of teplizumab to delay disease development. In this Perspective article, we discuss four major conceptual and practical issues that emerged as key to further advance type 1 diabetes research and therapies. First, collaborative networks leveraging the synergy between the type 1 diabetes research and care community ...

Sleep is a fundamental biological process essential for overall health and well-being. Studying it to diagnose sleep-wake disturbances requires overnight measurement of physiological signals, and annotation of these measurements through sleep staging. Traditionally, sleep studies are performed in the hospital using specialized polysomnography equipment and labor-intensive manual sleep staging. Wearable devices measuring brain activity and other ...

Neuropsychiatric symptoms are common and disabling in Parkinson's disease (PD), with troublesome anxiety occurring in one-third of patients. Management of anxiety in PD is challenging, hampered by insufficient insight into underlying mechanisms, lack of objective anxiety measurements, and largely ineffective treatments. In this study, we assessed the intracranial neurophysiological correlates of anxiety in PD patients treated with deep brain ...