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The evolution of patient-reported outcome measures after a first lateral ankle sprain: A prospective study KU Leuven

Kris Bogaerts
PURPOSE: A lateral ankle sprain is the most common musculoskeletal injury in the physically active population. However, it is unclear how the clinical condition evolves during the period after the injury and what proportion of patients develops chronic symptoms. Therefore, the purpose of this study is to assess the evolution of patient-reported outcome measures after a first time lateral ankle sprain. METHODS: A prospective clinical study ...

Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease: a secondary analysis from MARIPOSA KU Leuven

Christophe Dooms
BACKGROUND: Amivantamab-lazertinib significantly prolonged progression-free survival (PFS) versus osimertinib in patients with epidermal growth factor receptor (EGFR)-mutant advanced non-small-cell lung cancer [NSCLC; hazard ratio (HR) 0.70; P < 0.001], including those with a history of brain metastases (HR 0.69). Patients with TP53 co-mutations, detectable circulating tumor DNA (ctDNA), baseline liver metastases, and those without ctDNA ...

Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET KU Leuven

Steffi De Meyer, Isabelle Cleynen, Patrick Dupont, Koen Van Laere, Koen Poesen, Rik Vandenberghe
The dynamic phase of preclinical Alzheimer's disease, as characterized by accumulating cortical amyloid-β, is a window of opportunity for amyloid-β-lowering therapies to have greater efficacy. Biomarkers that accurately predict amyloid-β accumulation may be of critical importance for participant inclusion in secondary prevention trials and thus enhance development of early Alzheimer's disease therapies. We compared the abilities of baseline ...

Evaluation of the Effect of β-Wrapin AS69 in a Mouse Model Based on Alpha-Synuclein Overexpression KU Leuven

Chris Van den Haute, Veerle Baekelandt
Aggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegeneration. The engineered binding protein β-wrapin AS69 binds monomeric αSyn. AS69 reduces primary and secondary nucleation as well as fibril elongation in vitro. It also mitigates aSyn pathology in a mouse ...

Cracking the Ubiquitin Code of the RAS GTPases KU Leuven

Ubiquitination is one of the most prominent post-translational modifications in all eukaryotic systems. For decades, ubiquitination was mainly considered as a tag directing substrate proteins to proteasomal degradation. However, it has become more and more clear that ubiquitination can alter functioning of the target protein in many ways depending on the type of ubiquitin conjugation and target site of ubiquitination. In this project, we will ...

ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport KU Leuven

Chris Van den Haute, Veerle Baekelandt, Peter Vangheluwe
AIMS: Potential loss-of-function variants of ATP13A3, the gene encoding a P5B-type transport ATPase of undefined function, were recently identified in patients with pulmonary arterial hypertension (PAH). ATP13A3 is implicated in polyamine transport but its function has not been fully elucidated. In this study, we sought to determine the biological function of ATP13A3 in vascular endothelial cells (ECs) and how PAH-associated variants may ...

Google's Antitrust Quandary: Data Ecosystem Building Vrije Universiteit Brussel

Robin Vandendriessche, Seppe Maes, Caroline Buts

The judgement examined market definition and abusive practices in mobile application distribution agreements (MADAs), revenue sharing agreements (RSAs) and anti-fragmentation agreements (AFAs) by Google. The General Court largely upheld the Commission's decision, highlighting the interconnectedness of Google's anti-competitive restraints and categorised them as a single continuing infringement. The case provides a typical example of ...

Hollow Stair-Stepping Spherical High-Entropy Prussian Blue Analogue for High-Rate Sodium Ion Batteries KU Leuven

Elke Debroye, Johan Hofkens, Feili Lai
Prussian blue analogues (PBAs) are considered to be one of the most suitable sodium storage materials, especially with the introduction of the high-entropy (HE) concept into their structure to further improve their various abilities. However, severe agglomeration of the HEPBA particles still limits the fast charging capabilities. Here, an HEPBA (Nax(FeMnCoNiCu)[Fe(CN)6]y□1-y·nH2O) with a hollow stair-stepping spherical structure has been ...

Feasibility and efficacy of single-shot PFA technology for redo procedures after a previous atrial fibrillation ablation procedure Vrije Universiteit Brussel

Maria Cespon-Fernandez, Domenico Giovanni Della Rocca, I. Lombardo, Michele Magnocavallo, Andrés Betancur, Luigi Pannone, Antonio Sorgente, Roberto Menè, S. Bianci, Alexandre Almorad, et al.
Introduction: Despite significant technological advancements and a better understanding of atrial tachyarrhythmia pathophysiology, a non-negligible percentage of atrial fibrillation (AF) patients undergoing catheter ablation experiences arrhythmia relapse. Repeat procedures have been traditionally performed via thermal energy systems, which carry a certain risk of collateral damage to adjacent tissues. Pulsed Field Ablation (PFA) has emerged as ...

Extending the Scope of Conceptual Density Functional Theory with Second Order Analytical Methodologies Vrije Universiteit Brussel

Bin Wang, Paul Geerlings, Shubin Liu, Frank De Proft

In the context of the growing impact of conceptual density functional theory (DFT) as one of the most successful chemical reactivity theories, response functions up to second order have now been widely applied; in recent years, among others, particular attention has been focused on the linear response function and also extensions to higher order have been put forward. As the larger part of these studies have been carried using a finite ...