Publicaties
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MIP-based biomimetic sensor for the electronic detection of serotonin in human blood plasma Universiteit Hasselt KU Leuven
Serotonin is an important signaling molecule in the human body. The detection of serotonin is commonly performed by high performance liquid chromatography (HPLC), which is costly and time consuming due to extensive sample preparation. We will show that these problems can be overcome by using molecularly imprinted polymers (MIPs) as synthetic receptors in combination with impedance spectroscopy as readout technique. The MIPs were prepared with ...
Flow-cytometric identification of vinegars using a multi-parameter analysis optical detection module Vrije Universiteit Brussel
We show a proof-of-concept demonstration of a multi-parameter analysis low-cost optical detection system for the flow-cytometric identification of vinegars. This multi-parameter analysis system can simultaneously measure laser induced fluorescence, absorption and scattering excited by two time-multiplexed lasers of different wavelengths. To our knowledge no other polymer optofluidic chip based system offers more simultaneous measurements. The ...
Integrated confocal Raman probe combined with a free-form reflector based lab-on-chip Vrije Universiteit Brussel
Raman spectroscopy is a powerful tool for analytical measurements in many applications. Traditional Raman spectroscopic analyses require bulky equipment, considerable time of signal acquisition and manual sampling of substances under test. In this paper, we take a step from bulky and manual consuming laboratory testing towards lab-on-chip (LOC) analyses. We miniaturize the Raman spectroscopic system by combining a free-form reflector based ...
Optofluidic chip for single-beam optical trapping of particles enabling confocal raman measurements Vrije Universiteit Brussel Universiteit Gent
We present an optofluidic chip in polymethyl methacrylate (PMMA) that combines optical trapping of single particles with confocal Raman spectroscopy. We introduce the design of the optofluidic chip and the ray-tracing simulations combined with mathematical calculations used to determine the optical forces exerted on the particles and to model the excitation and collection of Raman scattering. The optical trapping is done using a single-beam ...
A novel optical technique for the detection of stone fragments in fruits. Vrije Universiteit Brussel
Because of the growing demand for healthy and high quality food products many efforts are made to develop new sensing systems for food analysis. In this work we demonstrate the use of a new technique for the detection of stone fragments in fruits, based on the transmission of laser light via scattering. The goal of our research was to develop a technique which could be used for the detection of stone fragments in a broad range of product types ...
Integrated polymer optofluidic chips Vrije Universiteit Brussel
We developed integrated plastic micro-optical detection units for absorbance and fluorescence measurements in various types of microfluidic channels. For each system we present the complete development process from optical design, to fabrication and proof-of-concept demonstration.
SERS biosensing of Sickle cell hemoglobin from Normal hemoglobin Vrije Universiteit Brussel
Hemoglobinopathies are the most common genetic disorders caused by a mutation in the genes encoding for one of the globin chains and leading to structural (hemoglobin [Hb] variants) or quantitative defects (thalassemias) in hemoglobin. Early diagnosis and characterization of hemoglobinopathies are essential to avoid severe hematological consequences in the offspring of healthy carriers of a mutation. Despite being extensively studied, ...
IIIU+2013V-on-silicon photonic integrated circuits for spectroscopic sensing in the 2U+20134 U+03BCm wavelength range Universiteit Gent
The availability of silicon photonic integrated circuits (ICs) in the 2-4 mu m wavelength range enables miniature optical sensors for trace gas and bio-molecule detection. In this paper, we review our recent work on III-V-on-silicon waveguide circuits for spectroscopic sensing in this wavelength range. We first present results on the heterogeneous integration of 2.3 mu m wavelength III-V laser sources and photodetectors on silicon photonic ICs ...
Improving food safety with optical screening Vrije Universiteit Brussel
Food safety has become increasingly important in our society. Today a major concern of the agriculture industry is the screening of two specific types of food contaminants imposing a key threat to health, being acrylamide formed during high-temperature processing and mycotoxins produced by toxic fungi. This doctoral thesis investigates the use of spectroscopic sensing techniques to non-destructively detect these harmful products, avoiding their ...