NOTCH pathway dysregulation is involved in impaired osteogenic differentiation of Mesenchymal stem cells derived from Multiple Myeloma Patients Vrije Universiteit Brussel
It is believed that bone marrow-derived mesenchymal stem cells in MM patients (MM-MSCs) harbor genetic and functional abnormalities. However, regarding the osteogenic differentiation ability of MM-MSCs, conflicting observations were reported. We observed that MM-MSCs, especially those from patients with bone lesions, exhibited significantly decreased alkaline phosphatase (ALP) activity, reduced expression of specific osteogenic markers (OPN, ...