Publicaties
Brain endothelial TAK1 and NEMO safeguard the neurovascular unit Vrije Universiteit Brussel KU Leuven
Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but the mechanisms underlying brain involvement were unclear. Here, we show that selectively deleting Nemo or the upstream kinase Tak1 in brain endothelial cells resulted in death of endothelial cells, a rarefaction of brain microvessels, cerebral ...
Location Matters: Navigating Regional Heterogeneity of the Neurovascular Unit. Vlaams Instituut voor Biotechnologie
Neuromuscular electrical stimulation as a possible mean to prevent muscle tissue wasting in artificially ventilated and sedated patients at the intensive care unit: a pilot study Universiteit Hasselt KU Leuven
Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices. Vlaams Instituut voor Biotechnologie KU Leuven
Spatially Self-Organized Three-Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development Vrije Universiteit Brussel KU Leuven
Although human pluripotent stem cell (PSC)-derived brain organoids have enabled researchers to gain insight into human brain development and disease, these organoids contain solely ectodermal cells and are not vascularized as occurs during brain development. Here it is created less complex and more homogenous large neural constructs starting from PSC-derived neuroprogenitor cells (NPC), by fusing small NPC spheroids into so-called ...